Association of Serum Alanine Aminotransferase Levels with Cardiometabolic Risk Factors in Normal-Weight and Overweight Children

被引:0
作者
Ghatreh-Samani, Shohreh [2 ]
Kelishadi, Roya [1 ,2 ]
Adibi, Atoosa [3 ]
Noori, Hengameh [2 ]
Moeini, Mina [1 ]
机构
[1] Isfahan Univ Med Sci, Child Hlth Promot Res Ctr, Esfahan, Iran
[2] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Esfahan, Iran
[3] Isfahan Univ Med Sci, Dept Radiol, Esfahan, Iran
关键词
Cardiometabolic Risk Factors; Fatty Liver; Children; Prevention; FATTY LIVER-DISEASE; HYPERTRIGLYCERIDEMIC WAIST PHENOTYPE; PEDIATRIC REFERENCE INTERVALS; METABOLIC SYNDROME; INSULIN-RESISTANCE; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; OBESE CHILDREN; IRANIAN CHILDREN; VISCERAL FAT;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: This study aimed to determine the prevalence of increased alanine aminotransferase (ALT), defined by a gender-specific cutoff value, among normal weight and overweight children; and to assess the relationship of increasing ALT levels with cardiometabolic risk factors. Methods: This cross-sectional study was conducted among school students, aged 6-18 years in Isfahan, Iran. Based on the body mass index (BMI) percentiles, a group of normal-weight was compared with a group of overweight and obese students. Gender differences were considered for increased levels of ALT, i.e. 19U/L and 30U/L for girls and boys respectively. Findings: The study participants consisted of 1172 students (56.2% girls), with a mean (SD) age of 12.57 (3.3) years. Among overweight/obese students the mean triglycerides (TG) and diastolic blood pressure was significantly higher in those with increased ALT than in those with normal ALT levels. The logistic regression analysis showed that among overweight/obese boys, for each 1 unit increase in ALT, the odds ratio (OR) of TG, total cholesterol and systolic blood pressure increased significantly. After, adjusting for age, these associations remained significant, and the OR of high density lipoprotein cholesterol (HDL-c) decreased significantly. In the model adjusting for age and BMI, the ORs of TG and HDL-c remained significant. After adjusting for age and waist circumference, HDL-c was the only parameter with significant OR. Among overweight/obese girls, in all models applied, the OR was significant for TG and total cholesterol. A significant independent association was documented for waist circumference and increase in ALT after adjustment for BMI. Conclusion: This study documented significant relationship of increased ALT levels, defined by a gender-specific cutoff point, with cardiometabolic risk factors and hypertriglyceridemic-waist phenotype in Iranian children and adolescents.
引用
收藏
页码:287 / 293
页数:7
相关论文
共 50 条
  • [41] ELEVATED CARDIOMETABOLIC RISK IN OVERWEIGHT AND CENTRALLY OBESE NORMAL WEIGHT SPANISH CHILDREN OF PRESCHOOL AGE
    Valvi, D.
    Dora, R.
    Jablonski, H. Bethany
    Amy, H.
    Martine, V.
    Salas, J.
    Mendez, M. A.
    ANNALS OF NUTRITION AND METABOLISM, 2013, 63 : 518 - 519
  • [42] Association of Irisin Plasma Levels with Anthropometric Parameters in Children with Underweight, Normal Weight, Overweight, and Obesity
    Elizondo-Montemayor, Leticia
    Silva-Platas, Christian
    Torres-Quintanilla, Alejandro
    Rodriguez-Lopez, Carlos
    Ruiz-Esparza, Guillermo U.
    Reyes-Mendoza, Eric
    Garcia-Rivas, Gerardo
    BIOMED RESEARCH INTERNATIONAL, 2017, 2017
  • [43] Metabolic factors are associated with serum alanine aminotransferase levels in patients with chronic hepatitis C
    Kobayashi, Yumi
    Kawaguchi, Yasunori
    Mizuta, Toshihiko
    Kuwashiro, Takuya
    Oeda, Satoshi
    Oza, Noriko
    Takahashi, Hirokazu
    Iwane, Shinji
    Eguchi, Yuichiro
    Anzai, Keizo
    Ozaki, Iwata
    Fujimoto, Kazuma
    JOURNAL OF GASTROENTEROLOGY, 2011, 46 (04) : 529 - 535
  • [44] Weight Change and Its Association with Cardiometabolic Risk Markers in Overweight and Obese Women
    Zamri, Liyana Ahmad
    Appannah, Geeta
    Sham, Siti Yazmin Zahari
    Mansor, Fazliana
    Ambak, Rashidah
    Nor, Noor Safiza Mohd
    Aris, Tahir
    JOURNAL OF OBESITY, 2020, 2020
  • [45] Association of polycyclic aromatic hydrocarbons with cardiometabolic risk factors and obesity in children
    Poursafa, Parinaz
    Dadvand, Payam
    Amin, Mohammad Mehdi
    Hajizadeh, Yaghoub
    Ebrahimpour, Karim
    Mansourian, Marjan
    Pourzamani, Hamidreza
    Sunyer, Jordi
    Kelishadi, Roya
    ENVIRONMENT INTERNATIONAL, 2018, 118 : 203 - 210
  • [46] Serum Alanine Aminotransferase and Its Association with Metabolic Syndrome in Children: The Bogalusa Heart Study
    Patel, Dharmendrakumar A.
    Srinivasan, Sathanur R.
    Chen, Wei
    Berenson, Gerald S.
    METABOLIC SYNDROME AND RELATED DISORDERS, 2011, 9 (03) : 211 - 216
  • [48] Postural balance under normal and altered sensory conditions in normal-weight and overweight children
    D'Hondt, Eva
    Deforche, Benedicte
    De Bourdeaudhuij, Ilse
    Gentier, Ilse
    Tanghe, Ann
    Shultz, Sarah
    Lenoir, Matthieu
    CLINICAL BIOMECHANICS, 2011, 26 (01) : 84 - 89
  • [49] Serum Alanine Aminotransferase Levels within Normal Range Have Different Associations with Augmentation Index and Other Cardiometabolic Risk Factors in Nondrinkers and Drinkers: A Chinese Community-Based Analysis
    Fu, Shihui
    Liu, Chunling
    Luo, Leiming
    Ye, Ping
    GASTROENTEROLOGY RESEARCH AND PRACTICE, 2017, 2017
  • [50] Insulin and leptin levels in overweight and normal-weight Iranian adolescents: The CASPIAN-III study
    Bahrami, Ehsan
    Mirmoghtadaee, Parisa
    Ardalan, Gelayol
    Zarkesh-Esfahani, Hamid
    Tajaddini, Mohammad Hassan
    Haghjooy-Javanmard, Shaghayegh
    Najafi, Hananeh
    Kelishadi, Roya
    JOURNAL OF RESEARCH IN MEDICAL SCIENCES, 2014, 19 (05): : 387 - 390