Bacterial invasion:: Force feeding by Salmonella

被引:52
作者
Brumell, JH [1 ]
Steele-Mortimer, O [1 ]
Finlay, BB [1 ]
机构
[1] Univ British Columbia, Biotechnol Lab, Vancouver, BC, Canada
关键词
D O I
10.1016/S0960-9822(99)80178-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent findings have shed new light on mammalian-cell invasion by Salmonella. Using a type III secretion system, Salmonella deliver virulence factors into the host cell that directly activate signal transduction pathways, initiating cytoskeletal rearrangements and bacterial uptake by a ruffling mechanism.
引用
收藏
页码:R277 / R280
页数:4
相关论文
共 18 条
[1]   Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins [J].
Carlson, SA ;
Jones, BD .
INFECTION AND IMMUNITY, 1998, 66 (11) :5295-5300
[2]   The invasion-associated type III system of Salmonella typhimurium directs the translocation of Sip proteins into the host cell [J].
Collazo, CM ;
Galan, JE .
MOLECULAR MICROBIOLOGY, 1997, 24 (04) :747-756
[3]   The invasion-associated type-III protein secretion system in Salmonella - A review [J].
Collazo, CM ;
Galan, JE .
GENE, 1997, 192 (01) :51-59
[4]   D-myo-inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways [J].
Eckmann, L ;
Rudolf, MT ;
Ptasznik, A ;
Schultz, C ;
Jiang, T ;
Wolfson, N ;
Tsien, R ;
Fierer, J ;
Shears, SB ;
Kagnoff, MF ;
Traynor-Kaplan, AE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (26) :14456-14460
[5]   The Salmonella typhimurium tyrosine phosphatase SptP is translocated into host cells and disrupts the actin cytoskeleton [J].
Fu, YX ;
Galán, JE .
MOLECULAR MICROBIOLOGY, 1998, 27 (02) :359-368
[6]   A secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa [J].
Galyov, EE ;
Wood, MW ;
Rosqvist, R ;
Mullan, PB ;
Watson, PR ;
Hedges, S ;
Wallis, TS .
MOLECULAR MICROBIOLOGY, 1997, 25 (05) :903-912
[7]   S-typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells [J].
Hardt, WD ;
Chen, LM ;
Schuebel, KE ;
Bustelo, XR ;
Galán, JE .
CELL, 1998, 93 (05) :815-826
[8]   Identification of a novel Salmonella invasion locus homologous to Shigella ipgDE [J].
Hong, KH ;
Miller, VL .
JOURNAL OF BACTERIOLOGY, 1998, 180 (07) :1793-1802
[9]   ENTRY OF MICROBES INTO THE HOST - USING M-CELLS TO BREAK THE MUCOSAL BARRIER [J].
JONES, B ;
PASCOPELLA, L ;
FALKOW, S .
CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (04) :474-478
[10]   Salmonellosis: Host immune responses and bacterial virulence determinants [J].
Jones, BD ;
Falkow, S .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :533-561