Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions

被引：187

作者：

Xia, Shanghua ^{[1
]}

Gan, Lu ^{[1
]}

Wang, Kaihang ^{[1
]}

Li, Zheng ^{[1
]}

Ma, Dawei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 41期

基金：

中国国家自然科学基金;

关键词：

HIGHLY EFFICIENT SYNTHESIS; ARYL HALIDES; SELECTIVE HYDROXYLATION; OXIDATIVE HYDROXYLATION; MESOPOROUS SILICA; ARYLBORONIC ACIDS; PHENOLS; CHLORIDES; WATER; HYDROXIDE;

D O I：

10.1021/jacs.6b08114

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of Cu(acac)(2) and N,N'-bis(4-hydroxyl-2,6-dimethylphenyl)oxalamide (BHMPO) provides a powerful catalytic system for hydroxylation of (hetero)aryl halides. A wide range of (hetero)aryl chlorides bearing either electron-donating or-withdrawing groups proceeded well at 130 degrees C, delivering the corresponding phenols and hydroxylated heteroarenes in good to excellent yields. When more reactive (hetero)aryl bromides and iodides were employed, the hydroxylation reactions completed at relatively low temperatures (80 and 60 degrees C, respectively) at low catalytic loadings (0.5 mol % Cu).

引用

收藏

页码：13493 / 13496

页数：4

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