A description of genes of Corynebacterium pseudotuberculosis useful in diagnostics and vaccine applications

被引：19

作者：

D'Afonseca, V. ^{[1
]}

Moraes, P. M. ^{[1
]}

Dorella, F. A. ^{[1
]}

Pacheco, L. G. C. ^{[1
]}

Meyer, R. ^{[2
]}

Portela, R. W. ^{[2
]}

Miyoshi, A. ^{[1
]}

Azevedo, V. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, ICB, Dept Biol Geral, Lab Genet Celular & Mol, Belo Horizonte, MG, Brazil

[2] UFBA, ICS, Dept Bioteracao, Lab Imunol & Biol Mol, Belo Horizonte, MG, Brazil

来源：

GENETICS AND MOLECULAR RESEARCH | 2008年 / 7卷 / 01期

关键词：

phospholipase D; RecA; caseous lymphadenitis;

D O I：

10.4238/vol7-1gmr438

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Corynebacterium pseudotuberculosis, a Gram-positive intracellular pathogen, is the etiological agent of caseous lymphadenitis or CLA. This bacterium infects goats and sheep and causes great economic losses worldwide annually, mainly for goat producers. Despite its importance, CLA is still poorly characterized. However, with advances in the genomic field, many C. pseudotuberculosis genes have already been characterized, mainly those related to virulence such as phospholipase D. Here, we examined the use of the several available genes of C. pseudotuberculosis and reviewed their applications in vaccine construction, more efficient diagnostics for CLA, and control of this disease, among other applications.

引用

页码：252 / 260

页数：9

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