Yolk Sac Tumor of the Thyroid Gland: A Case Report

被引：18

作者：

Furtado, Larissa V.

Leventaki, Vasiliki

Layfield, Lester J.

Lowichik, Amy ^{[1
,2
]}

Muntz, Harlan R. ^{[2
,3
]}

Pysher, Theodore J. ^{[1
,2
]}

机构：

[1] Univ Utah, Hlth Sci Ctr, Dept Pathol, Div Pediat Pathol, Salt Lake City, UT 84132 USA

[2] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA

[3] Univ Utah, Hlth Sci Ctr, Div Otolaryngol Head & Neck Surg, Dept Surg, Salt Lake City, UT USA

来源：

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 2011年 / 14卷 / 06期

关键词：

endodermal sinus tumor; pediatrics; thyroid gland; tumor of the head and neck; teratoma; yolk sac tumor; GERM-CELL; NEOPLASMS; HEAD;

D O I：

10.2350/11-01-0975-CR.1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Extragonadal yolk sac tumors are uncommon and usually seen in sacrococcygeal, mediastinal, intracranial, and retroperitoneal sites. Yolk sac tumors of the head and neck region are rare, and the few reported cases have arisen in neonates or infants in conjunction with a teratoma or other germ cell tumor subtypes. We report a unique case of a pure yolk sac tumor presenting as a primary lesion in the right thyroid lobe of a 10-year-old girl. The diagnosis was suspected after fine-needle aspiration, and extensive sampling of the thyroidectomy specimen revealed no teratoma or other germ cell tumor. Serum alpha-fetoprotein levels were markedly elevated 6 days after excision, and imaging disclosed numerous bilateral pulmonary nodules suggestive of metastatic disease but did not reveal a mediastinal mass. The tumor has shown a favorable response to bleomycin, etoposide, and cisplatin chemotherapy. To the best of our knowledge, this is the 1st description of a primary pure yolk sac tumor of the thyroid.

引用

页码：475 / 479

页数：5