Environmental factors in autoimmune diseases and their role in multiple sclerosis

被引：90

作者：

Joerg, Stefanie ^{[1
]}

Grohme, Diana A. ^{[2
]}

Erzler, Melanie ^{[2
]}

Binsfeld, Marilene ^{[4
,5
]}

Haghikia, Aiden ^{[6
]}

Mueller, Dominik N. ^{[7
]}

Linker, Ralf A. ^{[1
]}

Kleinewietfeld, Markus ^{[2
,3
,4
,5
]}

机构：

[1] Friedrich Alexander Univ FAU Erlangen Nuremberg, Univ Hosp Erlangen, Erlangen, Germany

[2] Tech Univ Dresden, Med Fac Carl Gustav Carus, Dept Clin Pathobiochem, Translat Immunol, Dresden, Germany

[3] CRTD, Dresden, Germany

[4] VIB Lab Translat Immunomodulat, Diepenbeek, Belgium

[5] Hasselt Univ, Diepenbeek, Belgium

[6] Ruhr Univ Bochum, Dept Neurol, Bochum, Germany

[7] Expt & Clin Res Ctr, Berlin, Germany

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2016年 / 73卷 / 24期

基金：

欧洲研究理事会;

关键词：

Autoimmunity; MS; CD4(+) T cells; Foxp3(+) Tregs; Th17; cells; Environmental risk factors; Microbiota; REGULATORY T-CELLS; ARYL-HYDROCARBON RECEPTOR; CHAIN FATTY-ACIDS; VITAMIN-D; GUT MICROBIOTA; HYGIENE HYPOTHESIS; DENDRITIC CELLS; TH17; CELLS; INTESTINAL MICROBIOTA; COMMENSAL MICROBIOTA;

D O I：

10.1007/s00018-016-2311-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An increase in autoimmune diseases poses a socioeconomic challenge worldwide. Predisposing genetic risk has been identified, yet environmental factors make up a significant part of the risk in disease initiation and propagation. Next to improved hygiene and a gross reduction of infections, changes in dietary habits are one of the most evident Western lifestyle factors potentially associated with the increase in autoimmune diseases. Growing evidence suggests that particularly a typical 'Western diet', rich in saturated fat and salt and related pathologies can have a profound impact on local and systemic immune responses under physiologic and autoimmune conditions such as in multiple sclerosis (MS). In this review, we discuss recent findings on environmental factors influencing autoimmunity with an emphasis on the impact of 'Western diet' on immune homeostasis and gut microbiota in MS.

引用

页码：4611 / 4622

页数：12

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