The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity

被引：51
作者：
Governini, Laura [6 ]
Orvieto, Raoul [4 ,5 ]
Guerranti, Cristiana [3 ]
Gambera, Laura [2 ]
De Leo, Vincenzo [2 ]
Piomboni, Paola [1 ,6 ]
机构：
[1] Univ Siena, S Maria alle Scotte Hosp, Ctr Diag & Treatment Couple Steril, Biol Sect,Dept Biomed Sci, I-53100 Siena, Italy
[2] Univ Siena, Dept Pediat Obstet & Reprod Med, I-53100 Siena, Italy
[3] Univ Siena, Dept Environm Sci G Sarfatti, I-53100 Siena, Italy
[4] Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel
[5] Barzilai Govt Hosp, Infertil & IVF Unit, Ashqelon, Israel
[6] Univ Siena, Appl Biol Sect, Dept Biomed Sci, I-53100 Siena, Italy
来源：
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2011年 / 28卷 / 05期
关键词：
Infertility; IVF; PFC contamination; Follicular fluid; PERFLUOROOCTANE SULFONATE; CHEMICALS; INUIT;
D O I：
10.1007/s10815-011-9548-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In an attempt to assess the effect of perfluorinated compounds (PFC) on oocytes quality and fertilization rate, we studied follicular fluid (FF) PFC levels in 18 patients undergoing IVF-ET cycles. A significant correlation (R = 0.75; P < 0.001) was observed between FF PFC levels and fertilization rate. Moreover, patients with FF PFC contamination had significantly lower fertilization rate (p < 0.02) and number of embryos transferred (p < 0.02), compared to the PFC negative group.
引用
收藏
页码：415 / 418
页数：4
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