Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy

被引：94

作者：

Marzocchetti, A ^{[1
]}

Di Giambenedetto, S ^{[1
]}

Cingolani, A ^{[1
]}

Ammassari, A ^{[1
]}

Cauda, R ^{[1
]}

De Luca, A ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Ist Clin Malattie Infett, Largo Gemelli 8, I-00168 Rome, Italy

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 08期

关键词：

D O I：

10.1128/JCM.43.8.4175-4177.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fifty-nine human immunodeficiency virus (HIV)-infected patients with suspected progressive multifocal leukoencephalopathy and 224 controls were tested for JC virus (JCV) DNA in cerebrospinal fluid by PCR. The diagnostic positive detection rate dropped from 89.5% (95% confidence intervals of 75.5 to 103.5%) in the pre-highly active antiretroviral therapy (HAART) era to 57.5% (95% confidence intervals of 42.1 to 72.9%) in the HAART era; the specificity remained unchanged. Predictors of failure to detect JCV DNA were exposure to HAART at disease onset and higher CD4 counts.

引用

页码：4175 / 4177

页数：3

共 16 条

[1] Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: Data from the Italian Registry Investigative Neuro AIDS (IRINA) [J].

Antinori, A ;

Cingolani, A ;

Lorenzini, P ;

Giancola, ML ;

Uccella, I ;

Bossolasco, S ;

Grisetti, S ;

Moretti, F ;

Vigo, B ;

Bongiovanni, M ;

Del Grosso, B ;

Arcidiacono, MI ;

Fibbia, GC ;

Mena, M ;

Finazzi, MG ;

Guaraldi, G ;

Ammassari, A ;

Monforte, AD ;

Cinque, P ;

De Luca, A .

JOURNAL OF NEUROVIROLOGY, 2003, 9 (Suppl 1) :47-53

[2] Diagnosis of AIDS-related focal brain lesions: A decision-making analysis based on clinical and neuroradiologic characteristics combined with polymerase chain reaction assays in CSF [J].

Antinori, A ;

Ammassari, A ;

DeLuca, A ;

Cingolani, A ;

Murri, R ;

Scoppettuolo, G ;

Fortini, M ;

Tartaglione, T ;

Larocca, LM ;

Zannoni, G ;

Cattani, P ;

Grillo, R ;

Roselli, R ;

Iacoangeli, M ;

Scerrati, M ;

Ortona, L .

NEUROLOGY, 1997, 48 (03) :687-694

[3] Epidemiology and prognosis of AIDS-associated progressive multifocal leukoencephalopathy in the HAART era [J].

Antinori, A ;

Ammassari, A ;

Giancola, ML ;

Cingolani, A ;

Grisetti, S ;

Murri, R ;

Alba, L ;

Ciancio, B ;

Soldani, F ;

Larussa, D ;

Ippolito, G ;

De Luca, A .

JOURNAL OF NEUROVIROLOGY, 2001, 7 (04) :323-328

[4]

Berger JR, 2001, J NEUROVIROL, V7, P329

[5] PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY - THE EVOLUTION OF A DISEASE ONCE CONSIDERED RARE [J].

BERGER, JR ;

CONCHA, M .

JOURNAL OF NEUROVIROLOGY, 1995, 1 (01) :5-18

[6] Progressive multifocal leukoencephalopathy [J].

Berger, JR ;

Major, EO .

SEMINARS IN NEUROLOGY, 1999, 19 (02) :193-200

[7] The evolving face of human immunodeficiency virus-related progressive multifocal leukoencephalopathy: Defining a consensus terminology [J].

Cinque, P ;

Koralnik, IJ ;

Clifford, DB .

JOURNAL OF NEUROVIROLOGY, 2003, 9 (Suppl 1) :88-92

[8] Clinical and virological monitoring during treatment with intrathecal cytarabine in patients with AIDS-associated progressive multifocal leukoencephalopathy [J].

De Luca, A ;

Giancola, ML ;

Cingolani, A ;

Ammassari, A ;

Gillini, L ;

Murri, R ;

Antinori, A .

CLINICAL INFECTIOUS DISEASES, 1999, 28 (03) :624-628

[9]

De Luca A, 2001, J NEUROVIROL, V7, P364

[10] The effect of potent antiretroviral therapy and JC virus load in cerebrospinal fluid on clinical outcome of patients with AIDS-associated progressive multifocal leukoencephalopathy [J].

De Luca, A ;

Giancola, ML ;

Ammassari, A ;

Grisetti, S ;

Paglia, MG ;

Gentile, M ;

Cingolani, A ;

Murri, R ;

Liuzzi, G ;

Monforte, AD ;

Antinori, A .

JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (04) :1077-1083

← 1 2 →