Effect of age, sex, and breed on serum cystatin C and creatinine concentrations in dogs

被引：2

作者：

Iwasa, Naoki ^{[1
,2
]}

Takashima, Satoshi ^{[2
]}

Iwasa, Tatsuo ^{[1
]}

Kumazawa, Rie ^{[1
]}

Nomura, Saki ^{[2
]}

Asami, Sara ^{[2
]}

Shimizu, Mamu ^{[2
]}

Kobatake, Yui ^{[2
]}

Nishii, Naohito ^{[2
]}

机构：

[1] Hashima Anim Hosp, 2-17 Asahira, Hashima, Gifu 5016255, Japan

[2] Gifu Univ, Fac Appl Biol Sci, Joint Dept Vet Med, 1-1 Yanagido, Gifu 5011193, Japan

来源：

VETERINARY RESEARCH COMMUNICATIONS | 2022年 / 46卷 / 01期

关键词：

Age; Creatinine; Cystatin C; Dog breed; Sex; GLOMERULAR-FILTRATION-RATE; RENAL-FUNCTION; REFERENCE RANGES; MARKER; DISEASE;

D O I：

10.1007/s11259-021-09844-w

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

This study investigated the effects of age, sex and breed on serum cystatin C (Cys-C) and creatinine in small breed dogs. This retrospective study included 250 dogs weighing less than 15 kg without azotemia. Serum Cys-C and creatinine concentrations were analyzed, along with their correlation with age, and the difference between sexes or dog breeds. Serum Cys-C concentration correlated with age (P < 0.001), and did not differ between sexes or dog breeds. By contrast, serum creatinine concentration did not correlate with age. Serum creatinine concentration was higher in males than females (P < 0.05), and was lower in Miniature Dachshunds and Chihuahuas, and was higher in Shiba Inus compared to the general study population (P < 0.001). Serum Cys-C concentration correlates with age, and might be more sensitive to aging-associated subclinical renal dysfunction than serum creatinine concentration in dogs. Unlike serum creatinine concentration, serum Cys-C concentration is not affected by sex or dog breed.

引用

页码：183 / 188

页数：6

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