An expedient synthesis of enantioenriched substituted (2-benzofuryl)arylcarbinols via tandem Rap-Stoermer and asymmetric transfer hydrogenation reactions

被引：26

作者：

Kumaraswamy, Gullapalli ^{[1
]}

Ramakrishna, Gajula ^{[1
]}

Raju, Ragam ^{[1
]}

Padmaja, Mogilisetti ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 3, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2010年 / 66卷 / 52期

关键词：

(Benzofuran-yl)-aryl and heteroaryl carbinols; Rap-Stoermer reaction; Asymmteric hydrogenation; Substituted salicylaldehyde; alpha-Haloaryl; heteroaryl ketones; ADRENOCEPTOR BLOCKING-AGENT; HYPOLIPIDEMIC ACTIVITY; BENZOFURANS; BUFURALOL; DIARYL; SERIES;

D O I：

10.1016/j.tet.2010.10.074

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient synthesis of enantioenriched substituted (benzofuran-yl)-aryl and heteroaryl carbinols, is described. A key feature of this protocol is synthesis of functionally varied benzofuran scaffolds via a Rap-Stoermer reaction/catalytic asymmetric transfer hydrogenation (ATH) using substituted salicylaldehyde and alpha-haloaryl, heteroaryl ketones. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：9814 / 9818

页数：5

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