Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility

被引：36

作者：

Scarel-Caminaga, Raquel M. ^{[1
]}

Kim, Yeon J. ^{[2
]}

Viana, Aline C. ^{[2
]}

Curtis, Karen M. C. ^{[1
]}

Corbi, Samia C. T. ^{[2
]}

Sogumo, Patricia M. ^{[1
]}

Orrico, Silvana R. P. ^{[2
]}

Cirelli, Joni A. ^{[2
]}

机构：

[1] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, BR-14801903 Araraquara, SP, Brazil

[2] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Araraquara, SP, Brazil

来源：

BIOCHEMICAL GENETICS | 2011年 / 49卷 / 5-6期

基金：

巴西圣保罗研究基金会;

关键词：

Interleukin; 8; Periodontitis; Polymorphism; Disease susceptibility; POLYMORPHISMS; DISEASE; RISK; VIRUS; IL8; POPULATION; SCLEROSIS; VARIANTS; HEALTH; LOCI;

D O I：

10.1007/s10528-010-9407-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed together with the previously investigated rs4073 (-251), were associated with chronic periodontitis susceptibility. Clinical periodontal exams were performed and DNA samples were collected from 493 individuals (223 with periodontitis and 270 controls). Associations between SNPs, haplotypes, and subject phenotypes were analyzed using the chi(2) test followed by multivariate logistic regression modeling. We conclude that the +396TT genotype and the haplotypes ATC/TTC and AGT/TGC were significantly associated with chronic periodontitis susceptibility in Brazilians.

引用

页码：292 / 302

页数：11

共 32 条

[1] Functional gene polymorphisms in aggressive and chronic periodontitis [J].

Brett, PM ;

Zygogianni, P ;

Griffiths, GS ;

Tomaz, M ;

Parkar, M ;

D'Aiuto, F ;

Tonetti, M .

JOURNAL OF DENTAL RESEARCH, 2005, 84 (12) :1149-1153

[2] Associations of classic Kaposi sarcoma with common variants in genes that modulate host immunity [J].

Brown, Elizabeth E. ;

Fallin, Daniele ;

Ruczinski, Ingo ;

Hutchinson, Amy ;

Staats, Brian ;

Vitale, Francesco ;

Lauria, Carmela ;

Serraino, Diego ;

Rezza, Giovanni ;

Mbisa, Georgina ;

Whitby, Denise ;

Messina, Angelo ;

Goedert, James J. ;

Chanock, Stephen J. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (05) :926-934

[3]

Callegari-Jacques Sidia M., 1999, Ciencia e Cultura (Sao Paulo), V51, P166

[4] Lack of association between-251 T>A polymorphism of IL8 and lung cancer risk [J].

Campa, D ;

Hung, RJ ;

Mates, D ;

Zaridze, D ;

Szeszenia-Dabrowska, N ;

Rudnai, P ;

Lissowska, J ;

Fabiánová, E ;

Bencko, V ;

Foretova, L ;

Janout, V ;

Boffetta, P ;

Brennan, P ;

Canzian, F .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (10) :2457-2458

[5] Polymorphisms in the vitamin D receptor gene are associated with periodontal disease [J].

de Brito, RB ;

Scarel-Caminaga, RMS ;

Trevilatto, PC ;

de Souza, AP ;

Barros, SP .

JOURNAL OF PERIODONTOLOGY, 2004, 75 (08) :1090-1095

[6] Increased presence of interleukin-6 (IL-6) and IL-8 secreting fibroblast subpopulations in adult periodontitis [J].

Dongari-Bagtzoglou, AI ;

Ebersole, JL .

JOURNAL OF PERIODONTOLOGY, 1998, 69 (08) :899-910

[7] Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility [J].

Hacking, D ;

Knight, JC ;

Rockett, K ;

Brown, H ;

Frampton, J ;

Kwiatkowski, DP ;

Hull, J ;

Udalova, IA .

GENES AND IMMUNITY, 2004, 5 (04) :274-282

[8] Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families [J].

Hull, J ;

Thomson, A ;

Kwiatkowski, D .

THORAX, 2000, 55 (12) :1023-1027

[9] Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus [J].

Hull, J ;

Ackerman, H ;

Isles, K ;

Usen, S ;

Pinder, M ;

Thomson, A ;

Kwiatkowski, D .

AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (02) :413-419

[10] Significant association of interleukin 8-251T/A polymorphism with smoking behavior in a Japanese population [J].

Ito, H ;

Matsuo, K ;

Hamajima, N ;

Okuma, K ;

Saito, T ;

Tajima, K .

JOURNAL OF HUMAN GENETICS, 2005, 50 (11) :567-573

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