Baeyer-Villiger oxidations: biotechnological approach

被引：92

作者：

Bucko, Marek ^{[1
]}

Gemeiner, Peter ^{[1
]}

Schenkmayerova, Andrea ^{[1
]}

Krajcovic, Tomas ^{[1
]}

Rudroff, Florian ^{[2
]}

Mihovilovic, Marko D. ^{[2
]}

机构：

[1] Slovak Acad Sci, Ctr Glyc, Dept Glycobiotechnol, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia

[2] TU Wien, Inst Appl Synthet Chem, Getreidemarkt 9-163, A-1060 Vienna, Austria

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2016年 / 100卷 / 15期

关键词：

Baeyer-Villiger monooxygenases; Cascade reactions; Whole-cell immobilization; Polyelectrolyte complex capsules; Asymmetric synthesis; Biocatalysis; RECOMBINANT ESCHERICHIA-COLI; ENZYME CASCADE SYNTHESIS; WHOLE-CELL BIOCATALYST; CYCLOHEXANONE MONOOXYGENASE; ALCOHOL-DEHYDROGENASE; EPSILON-CAPROLACTONE; ORGANIC-SYNTHESIS; FLAVOPROTEIN MONOOXYGENASES; PSEUDOMONAS-PUTIDA; PROTEIN-SEQUENCE;

D O I：

10.1007/s00253-016-7670-x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Baeyer-Villiger monooxygenases ( BVMOs) are a very well-known and intensively studied class of flavin-dependent enzymes. Their substrate promiscuity, high chemo-, regio-, and enantioselectivity are prerequisites for the use in synthetic chemistry and should pave the way for successful industrial processes. Nonetheless, only a very limited number of industrial relevant transformations are known, mainly due to the lack of BVMOs stability and cofactor dependency. In this review, we focus on novel BVMO-mediated transformations, BVMOs in cascade type reactions, potential industrial applications, and how limitations have been tackled by the community. Special attention will be put on whole-cell immobilization strategies. We emphasize to bridge recent developments in fundamental research to industrial applications.

引用

页码：6585 / 6599

页数：15

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