Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients

被引：232

作者：

Yuan, Yuan ^{[1
]}

Liu, Lingxiang ^{[1
,2
]}

Chen, Hu ^{[1
,3
]}

Wang, Yumeng ^{[1
,3
]}

Xu, Yanxun ^{[4
]}

Mao, Huzhang ^{[5
,6
]}

Li, Jun ^{[1
]}

Mills, Gordon B. ^{[7
]}

Shu, Yongqian ^{[2
]}

Li, Liang ^{[5
]}

Liang, Han ^{[1
,3
,7
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[2] Nanjing Med Univ, Affiliated Hosp 1, Dept Oncol, Nanjing 210029, Jiangsu, Peoples R China

[3] Baylor Coll Med, Grad Program Struct & Computat Biol & Mol Biophys, Houston, TX 77030 USA

[4] Johns Hopkins Univ, Dept Appl Math & Stat, Baltimore, MD 21218 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA

[6] Univ Texas Hlth Sci Ctr Houston, Dept Biostat, Houston, TX 77030 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77030 USA

来源：

CANCER CELL | 2016年 / 29卷 / 05期

基金：

中国国家自然科学基金;

关键词：

CELL LUNG-CANCER; PROPENSITY SCORE; TARGETS; SEX; GENDER; METABOLISM; INHIBITORS; CHROMOSOME; EXPRESSION; PREDICTION;

D O I：

10.1016/j.ccell.2016.04.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.

引用

页码：711 / 722

页数：12

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