A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells

被引：24
作者：
Wang, Menghua [2 ]
Xia, Yi [1 ]
Fan, Yuting [2 ]
Rocchi, Palma [3 ]
Qu, Fanqi [2 ]
Iovanna, Juan L. [3 ]
Peng, Ling [1 ]
机构：
[1] CINaM, CNRS, Dept Chim, UPR 3118, F-13288 Marseille, France
[2] Wuhan Univ, Coll Chem & Mol Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
[3] INSERM, U624, F-13288 Marseille, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 20期
基金：
美国国家科学基金会;
关键词：
Acyclic nucleosides; Triazole nucleosides; Pancreatic cancer; Anticancer activity; Sonogashira reaction; SPECTRUM ANTIVIRAL ACTIVITY; TOBACCO-MOSAIC-VIRUS; HEPATITIS-C VIRUS; SHOCK-PROTEIN; 27; BITRIAZOLYL COMPOUNDS; THERAPEUTIC TARGETS; ANTICANCER ACTIVITY; HUISGEN REACTION; GEMCITABINE; NUCLEOSIDES;
D O I：
10.1016/j.bmcl.2010.08.093
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Novel arylethynyltriazole acyclonucleosides were synthesized and assessed for their anticancer activity on drug-resistant pancreatic cancer MiaPaCa-2 cells. One lead compound was found to have much more potent apoptosis-related antiproliferative effects than gemcitabine, the current first-line treatment for pancreatic cancer. Further investigations showed that this active compound did not inhibit DNA synthesis, which means that it does not resemble gemcitabine and may involve a different mechanism of action. (c) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5979 / 5983
页数：5
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