Gastrointestinal Involvement in SARS-CoV-2 Infection

被引：39

作者：

Chen, Tsung-Hsien ^{[1
]}

Hsu, Ming-Tse ^{[2
]}

Lee, Ming-Yang ^{[1
,3
,4
]}

Chou, Chu-Kuang ^{[2
,5
,6
]}

机构：

[1] Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Internal Med, Chiayi 60002, Taiwan

[2] Ditmanson Med Fdn Chia Yi Christian Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Chiayi 60002, Taiwan

[3] Ditmanson Med Fdn Chia Yi Christian Hosp, Div Hematooncol, Dept Internal Med, Chiayi 60002, Taiwan

[4] Min Hwei Jr Coll Hlth Care Management, Tainan 73658, Taiwan

[5] Ditmanson Med Fdn Chia Yi Christian Hosp, Obes Ctr, Chiayi 60002, Taiwan

[6] Ditmanson Med Fdn Chia Yi Christian Hosp, Clin Trial Ctr, Chiayi 60002, Taiwan

来源：

VIRUSES-BASEL | 2022年 / 14卷 / 06期

关键词：

SARS-CoV-2; gastrointestinal involvement; prevention; oral vaccine; microbiota; CORONAVIRUS INFECTION; ORAL IMMUNIZATION; COVID-19; ACE2; RECEPTOR; SARS; MANIFESTATIONS; EXPRESSION; TMPRSS2; CELLS;

D O I：

10.3390/v14061188

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SARS-CoV-2 has evolved into a virus that primarily results in mild or asymptomatic disease, making its transmission more challenging to control. In addition to the respiratory tract, SARS-CoV-2 also infects the digestive tract. Some gastrointestinal symptoms occur with or before respiratory symptoms in patients with COVID-19. Respiratory infections are known to cause intestinal immune impairment and gastrointestinal symptoms. When the intestine is inflamed, cytokines affect the lung immune response and inflammation through blood circulation. The gastrointestinal microbiome may be a modifiable factor in determining the risk of SARS-CoV-2 infection and disease severity. The development of oral SARS-CoV-2 vaccine candidates and the maintenance of gut microbiota profiles may contribute to the early control of COVID-19 outbreaks. To this end, this review summarizes information on the gastrointestinal complications caused by SARS-CoV-2, SARS-CoV-2 infection, the gastrointestinal-lung axis immune response, potential control strategies for oral vaccine candidates and maintaining intestinal microbiota homeostasis.

引用

页数：17

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