Flow profile near a wall measured by double-focus fluorescence cross-correlation -: art. no. 056313

被引:79
作者
Lumma, D
Best, A
Gansen, A
Feuillebois, F
Rädler, JO
Vinogradova, OI
机构
[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany
[2] Ecole Super Phys & Chim Ind Ville Paris, Phys & Mecan Milieux Heterogenes Lab, F-75231 Paris 05, France
[3] Russian Acad Sci, Inst Phys Chem, Lab Phys Chem Modified Surfaces, Moscow 117915, Russia
来源
PHYSICAL REVIEW E | 2003年 / 67卷 / 05期
关键词
D O I
10.1103/PhysRevE.67.056313
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
We present an experimental approach to flow profiling within femtoliter sample volumes, which allows the high-precision measurements at the solid interface. The method is based on the spatial cross-correlation of the fluorescence response from labeled tracer particles (latex nanospheres or single dye molecules). Two excitation volumes, separated by a few micrometers, are created by two laser foci under a confocal microscope. The velocity of tracer particles is measured in a channel about 100 mum wide within a typical accuracy of 0.1%, and the positions of the walls are estimated independently of any hydrodynamic data. The underlying theory for the optical method is given for an arbitrary velocity profile, explicitly presenting the numerical convolutions necessary for a quantitative analysis. It is illustrated by using the Poiseuille flow of a Newtonian liquid with slip as an example. Our analysis yields a large apparent fluid velocity at the wall, which is mostly due to the impact of the colloidal (electrostatic) forces. This colloidal lift is crucially important in accelerating the transport processes of molecules and nanoparticles in microfluidic devices.
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页数:10
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