Effectiveness of Antimicrobial Photodynamic Therapy in the Treatment of Periodontitis: A Systematic Review and Meta-Analysis of In Vivo Human Randomized Controlled Clinical Trials

被引:21
作者
Dalvi, Snehal [1 ,2 ]
Benedicenti, Stefano [1 ]
Salagean, Tudor [3 ]
Bordea, Ioana Roxana [4 ]
Hanna, Reem [1 ,5 ]
机构
[1] Univ Genoa, Laser Therapy Ctr, Dept Surg Sci & Integrated Diagnost, Viale Benedetto XV,6, I-16132 Genoa, Italy
[2] Swargiya Dadasaheb Kalmegh Smruti Dent Coll & Hos, Dept Periodontol, Nagpur 441110, Maharashtra, India
[3] Univ Agr Sci & Vet Med Cluj Napoca, Dept Land Measurements & Exact Sci, Cluj Napoca 400372, Romania
[4] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Oral Rehabil, Cluj Napoca 400012, Romania
[5] Kings Coll Hosp NHS Fdn Trust, Dent Inst, Dept Oral Surg, London SE5 9RS, England
关键词
antimicrobial photodynamic therapy; periodontitis; scaling and root planing; systematic review; meta-analysis; GINGIVAL CREVICULAR FLUID; AGGRESSIVE PERIODONTITIS; NONSURGICAL TREATMENT; DIODE-LASER; RESIDUAL POCKETS; INDOCYANINE GREEN; DOUBLE-BLIND; ADJUNCT; ANTIBIOTICS; AMOXICILLIN;
D O I
10.3390/pharmaceutics13060836
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This systematic review and meta-analysis evaluated antimicrobial photodynamic therapy (aPDT) efficacy in periodontitis. The review protocol was conducted in accordance with PRISMA statements, Cochrane Collaboration recommendations and is registered in PROSPERO (CRD 42020161516). Electronic and hand search strategies were undertaken to gather data on in vivo human RCTs followed by qualitative analysis. Differences in probing pocket depth (PPD) and clinical attachment level (CAL) were calculated with 95% confidence intervals and pooled in random effects model at three and six months. Heterogeneity was analyzed, using Q and I-2 tests. Publication bias was assessed by visual examination of the funnel plot symmetry. Sixty percent of 31 eligible studies showed a high risk of bias. Meta-analysis on 18 studies showed no additional benefit in split mouth studies in terms of PPD reduction (SMD 0.166; 95% CI -0.278 to 0.611; P = 0.463) and CAL gain (SMD 0.092; 95% CI -0.013 to 0.198; P = 0.088). Similar findings noted for parallel group studies; PPD reduction (SMD 0.076; 95% CI -0.420 to 0.573; P = 0.763) and CAL gain (SMD 0.056; 95% CI -0.408 to 0.552; P = 0.745). Sensitivity analysis minimized heterogeneity for both outcome variables; however, intergroup differences were not statistically significant. Future research should aim for well-designed RCTs in order to determine the effectiveness of aPDT.
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页数:42
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