Synthesis, antimalarial and antioxidant activity of coumarin appended 1,4-disubstituted 1,2,3-triazoles

被引：38

作者：

Kaushik, C. P. ^{[1
]}

Chahal, Manisha ^{[1
]}

机构：

[1] Guru Jambheshwar Univ Sci & Technol, Dept Chem, Hisar 125001, Haryana, India

来源：

MONATSHEFTE FUR CHEMIE | 2021年 / 152卷 / 08期

关键词：

Coumarin; 1,4-Disubstituted 1,2,3-triazoles; Click chemistry; Antimalarial activity; Antioxidant activity; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; CLICK CHEMISTRY; ANTIMICROBIAL EVALUATION; TRIAZOLE DERIVATIVES; ANTICANCER ACTIVITY; DESIGN; INHIBITORS; ANTIBACTERIAL; ANTITUMOR;

D O I：

10.1007/s00706-021-02821-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of coumarin appended triazole hybrids of biotic interest was synthesized through click chemistry approach from the coumarin based terminal alkynes and aromatic azides. All the synthesized triazoles were characterized by FT-IR, H-1 NMR, C-13 NMR, and HRMS and assessed for antimalarial activities against plasmodium falciparum strain. Results revealed that most of the synthesized coumarin-triazole hybrid compounds possess moderate to good activity. Further, the synthesized coumarin triazole hybrids were employed for antioxidant activities and were found to be potent antioxidant when compared with standard drug. [GRAPHICS] .

引用

页码：1001 / 1012

页数：12

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