Colloids containing gadolinium-capped gold nanoparticles as high relaxivity dual-modality contrast agents for CT and MRI

被引：15

作者：

Zeng, ChengCai ^{[1
]}

Shi, XiaoNi ^{[1
]}

Wu, Bo ^{[1
]}

Zhang, Dong ^{[1
]}

Zhang, WeiLu ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Zhejiang, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2014年 / 123卷

关键词：

Colloid; Contrast agents; Gold nanoparticles; MRI/CT dual-modality; Gadolinium; STABILITY; NANORODS;

D O I：

10.1016/j.colsurfb.2014.09.007

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A type of novel macromolecular colloid was prepared from gadolinium-based poly(L-succinimide) and gold nanoparticles (GNPs) with Au-S covalent bonds. The colloid displayed improved stability in aqueous media and regular arrays in partial region. Moreover, these materials enhanced the contrast 9 times more than that of the corresponding uncoated Au compound when the Au mass content was only 0.15%. Therefore, these materials might have potential as dual-modality contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT). (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：130 / 135

页数：6

共 17 条

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