Better outcomes of COVID-19 in vaccinated compared to unvaccinated patients with systemic rheumatic diseases

被引：45

作者：

Papagoras, Charalampos ^{[1
]}

Fragoulis, George E. ^{[2
]}

Zioga, Nikoleta ^{[3
]}

Simopoulou, Theodora ^{[4
]}

Deftereou, Kleopatra ^{[5
]}

Kalavri, Eleni ^{[6
]}

Zampeli, Evangelia

Gerolymatou, Nafsika ^{[9
]}

Kataxaki, Evangelia ^{[7
,8
,10
]}

Melissaropoulos, Konstantinos ^{[11
]}

Panopoulos, Stylianos ^{[2
]}

Fragiadaki, Kalliopi ^{[2
]}

Evangelatos, Gerasimos ^{[2
]}

Bournia, Vasiliki-Kalliopi ^{[2
]}

Arida, Aikaterini ^{[2
]}

Karamanakos, Anastasios ^{[2
]}

Pappa, Maria ^{[2
]}

Panagiotopoulos, Alexandros ^{[12
]}

Koutsianas, Christos ^{[12
]}

Mparouta, Georgia ^{[13
]}

Dimitroulas, Theodoros ^{[5
]}

Liossis, Stamatis-Nick ^{[14
]}

Tektonidou, Maria G. ^{[2
]}

Kravvariti, Evrydiki ^{[2
]}

Kougkas, Nikolaos ^{[5
]}

Georgiou, Panagiotis ^{[11
]}

Voulgari, Paraskevi ^{[9
]}

Elezoglou, Antonia ^{[6
]}

Bogdanos, Dimitrios P. ^{[4
]}

Vassilopoulos, Dimitrios ^{[12
]}

Sfikakis, Petros P. ^{[2
]}

机构：

[1] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Internal Med 1, Alexandroupolis, Greece

[2] Natl & Kapodistrian Univ Athens, Joint Acad Rheumatol Program, Sch Med, Dept Propedeut Internal Med 1, Athens, Greece

[3] Democritus Univ Thrace, Dept Internal Med 1, Komotini, Greece

[4] Univ Hosp Larissa, Clin Rheumatol & Clin Immunol, Larisa, Greece

[5] Aristotle Univ Thessaloniki, Dept Internal Med 4, Thessaloniki, Greece

[6] Asklepie Gen Hosp, Dept Rheumatol, Athens, Greece

[7] Inst Autoimmune Syst & Neurol Dis, Athens, Greece

[8] Iaso Hosp, Dept Rheumatol, Athens, Greece

[9] Univ Ioannina, Rheumatol Clin, Sch Med, Ioannina, Greece

[10] Gen Hosp Elefsinas Thriaseio, Dept Rheumatol, Athens, Greece

[11] Agios Andreas Hosp, Dept Rheumatol, Patras, Greece

[12] Natl & Kapodistrian Univ Athens, Dept Med & Lab, Clin Immunol Rheumatol Unit, Joint Acad Rheumatol Program, Athens, Greece

[13] Private Rheumatol Off, Kardhitsa, Greece

[14] Univ Patras, Dept Internal Med, Med Sch, Patras, Greece

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2022年 / 81卷 / 07期

关键词：

COVID-19; autoimmune diseases; vaccination;

D O I：

10.1136/annrheumdis-2021-221539

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective tau o report outcomes of breakthrough COVID-19 in comparison with COVID-19 in unvaccinated patients with systemic rheumatic diseases (SRDs). Methods Patients with SRD with COVID-19 (vaccinated and unvaccinated) were included by their rheumatologists in a registry operated by the Greek Rheumatology Society in a voluntarily basis. Type, date and doses of SARS-CoV-2 vaccines were recorded, and demographics, type of SRD, concurrent treatment, comorbidities and COVID-19 outcomes (hospitalisation, need for oxygen supplementation and death) were compared between vaccinated and unvaccinated patients. Results Between 1 March 2020 and 31 August 2021, 195 patients with SRD with COVID-19 were included; 147 unvaccinated and 48 vaccinated with at least one dose of a SARS-CoV-2 vaccine (Pfizer n=38 or AstraZeneca n=10). Among vaccinated patients, 29 developed breakthrough COVID-19 >14 days after the second vaccine dose (fully vaccinated), while 19 between the first and <14 days after the second vaccine dose (partially vaccinated). Despite no differences in demographics, SRD type, treatment or comorbidities between unvaccinated and vaccinated patients, hospitalisation and mortality rates were higher in unvaccinated (29.3% and 4.1%, respectively) compared with partially vaccinated (21% and 0%) or fully vaccinated (10.3% and 0%) patients. Conclusions Vaccinated patients with SRD with breakthrough COVID-19 have better outcomes compared with unvaccinated counterparts with similar disease/treatment characteristics.

引用

页码：1013 / 1016

页数：4

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