Characterization of Differences in Functional Connectivity Associated with Close-Range Blast Exposure

被引:29
作者
Robinson, Meghan E. [1 ,2 ,4 ]
Clark, Dustin C. [1 ]
Milberg, William P. [2 ,3 ,5 ]
McGlinchey, Regina E. [2 ,3 ,5 ]
Salat, David H. [1 ,2 ]
机构
[1] VA Boston Healthcare Syst, Neuroimaging Res Vet NeRVe Ctr, 150 South Huntington Ave, Boston, MA 02132 USA
[2] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS, Natl Res Ctr, Boston, MA 02132 USA
[3] VA Boston Healthcare Syst, GRECC, Boston, MA 02132 USA
[4] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
[5] Harvard Med Sch, Dept Psychiat, Boston, MA USA
关键词
adult brain injury; military injury; MRI; TRAUMATIC BRAIN-INJURY; SURFACE-BASED ANALYSIS; CONCUSSIVE BLAST; SIGNAL; MODEL; SEGMENTATION; FLUCTUATIONS; POPULATIONS; EXPRESSION; VARIANCE;
D O I
10.1089/neu.2016.4709
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Despite the prevalence of blast injuries in recent overseas conflicts, knowledge of their impact on neural health is lacking. We have recently published work demonstrating differences in functional magnetic resonance imaging (fMRI) connectivity that were specific to close-range blast exposure (CBE), as opposed to other prevalent military-related factors. Here, we replicate this finding in an independent sample of 135 veterans, again finding that CBE, regardless of concussion, is predictive of persistent changes in brain physiology. Although there was weak overlap anatomically, in both samples, the group differences could be described as spreading of anticorrelation. Using the combined sample, we now seek to identify likely mechanisms that could bring about this effect. We compared participants with (n=116) and without (n=153) CBE by analyzing two networks through group difference maps and correlation distributions to assess spatially homogenous and heterogeneous effects. As boundaries between positive and negative correlations in fcMRI are determined by noise covariates, we compared analyses with and without global signal regression. We found evidence of widespread altered connectivity that was spatially heterogeneous across participants, and that the role of global signal regression was network dependent. These findings are not consistent with expected results from damaged white matter or impaired neural function. Rather, potential biological interpretations include disrupted cerebral blood flow or impaired neurovascular coupling, which have each been observed in animal models of blast exposure. Further targeted work will be necessary to distinguish the contribution of each of these mechanisms to producing changes in brain function associated with CBE.
引用
收藏
页码:S53 / S61
页数:9
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