Therapeutic effects of ecabet sodium, an antiulcer drug, on dextran sodium sulfate-induced ulcerative colitis in rats

被引：6

作者：

Noto, T ^{[1
]}

Yamada, H ^{[1
]}

Inui, T ^{[1
]}

Okuyama, K ^{[1
]}

Watanable, A ^{[1
]}

Kimura, I ^{[1
]}

Nagasaki, M ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Discovery & Pharmacol Res Labs, Toda, Saitama 3358505, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2005年 / 50卷 / 05期

关键词：

restitution; leukotriene B-4; TGF beta; 5-lipoxygenase;

D O I：

10.1007/s10620-005-2665-y

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Ecabet, an antiulcer drug, is reported to be effective in patients with ulcerative colitis. We investigated the effect of ecabet enema on ulcerative colitis in rats and some mechanisms underlying this effect. In vivo ecabet enema showed a therapeutic effect in the rat ulcerative colitis model induced by dextran sodium sulfate in the drinking water. The amount of ecabet bound to damaged mucosa was higher than that bound to normal mucosa 30 min after intrarectal administration. In vitro ecabet accelerated the restitution of epithelial cells, which was not affected by a TGF-beta antibody. Ecabet inhibited the leukotriene B-4 production and 5-lipoxygenase activity in human neutrophils. In conclusion, ecabet enema showed a therapeutic effect in rats with ulcerative colitis. This effect may be attributable to the high binding affinity for damaged mucosa, the acceleration of restitution, and the inhibition of leukotriene B-4 production.

引用

页码：922 / 927

页数：6

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