Circulating Haptoglobin and Metabolic Syndrome in Renal Transplant Recipients

被引：10

作者：

Minovic, Isidor ^{[1
,2
,3
]}

Eisenga, Michele F. ^{[1
]}

Riphagen, Ineke J. ^{[1
]}

van den Berg, Else ^{[1
]}

Kootstra-Ros, Jenny ^{[3
]}

Frenay, Anne-Roos S. ^{[4
]}

van Goor, Harry ^{[4
]}

Rimbach, Gerald ^{[5
]}

Esatbeyoglu, Tuba ^{[5
]}

Levy, Andy P. ^{[6
]}

Gaillard, Carlo A. J. M. ^{[1
]}

Geleijnse, Johanna M. ^{[7
]}

Eggersdorfer, Manfred L. ^{[8
]}

Navis, Gerjan J. ^{[1
]}

Kema, Ido P. ^{[3
]}

Bakker, Stephan J. L. ^{[1
,2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Div Nephrol, Dept Internal Med, Hanzepl 1, NL-9700 RB Groningen, Netherlands

[2] Top Inst Food & Nutr, Nieuwe Kanaal 9-A, NL-6709 PA Wageningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, Hanzepl 1, NL-9700 RB Groningen, Netherlands

[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol, Hanzepl 1, NL-9700 RB Groningen, Netherlands

[5] Christian Albrechts Univ Kiel, Inst Human Nutr & Food Sci, Kiel, Germany

[6] Technion Israel Inst Technol, Fac Med, Efron St 1, Haifa, Israel

[7] Wageningen Univ, Div Human Nutr, Droevendaalsesteeg 4, NL-6708 PB Wageningen, Netherlands

[8] DSM Nutr Prod, Wurmisweg 576, CH-4303 Kaiseraugst, Switzerland

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; MULTIPLE IMPUTATION; INSULIN-RESISTANCE; PROTEIN; OBESITY; MORTALITY; MARKER; RISK; HEMOGLOBIN; VALIDATION;

D O I：

10.1038/s41598-017-14302-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Haptoglobin (Hp) is an acute phase protein that has recently been linked to components of the metabolic syndrome (MetS). We aimed to evaluate Hp as marker of MetS, and to assess its association with long-term outcome in renal transplant recipients (RTR). We measured plasma Hp in a prospective cohort of 699 stable RTR and 149 healthy controls. Median plasma Hp concentration in RTR was 1.4 [interquartile range (IQR), 1.0-1.8] g/L, which was higher compared to 1.1 [0.9-1.4] g/L in controls (P < 0.001). Hp was independently associated with the MetS (beta = 0.10) (P = 0.005). During follow-up of 5.4 [4.8-6.1] years, 150 (21%) recipients died, of whom 60 (9%) due to cardiovascular causes, and 83 (12%) RTR developed graft failure. High (>= 2.0 g/L) and low (<= 0.9 g/L) plasma Hp were associated with increased risk of mortality (HR's 2.3 [1.3-4.1] and 1.9 [1.0-3.5], resp.), predominantly cardiovascular. The association of high Hp lost significance upon adjustment for inflammation markers (HR 1.5 [0.8-2.7]), while low Hp was independently associated with mortality (HR 2.2 [1.2-4.0]). Hp was not associated with graft failure (P = 0.49). In conclusion, plasma Hp is independently associated with MetS in RTR. Importantly, high and low Hp are associated with increased mortality risk, independent of MetS.

引用

页数：9

共 45 条

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