Induction of virus resistance by exogenous application of double-stranded RNA

被引：92

作者：

Mitter, Neena ^{[1
]}

Worrall, Elizabeth A. ^{[1
]}

Robinson, Karl E. ^{[1
]}

Xu, Zhi Ping ^{[2
]}

Carroll, Bernard J. ^{[3
]}

机构：

[1] Univ Queensland, Queensland Alliance Agr & Food Innovat, Brisbane, Qld 4072, Australia

[2] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[3] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia

来源：

CURRENT OPINION IN VIROLOGY | 2017年 / 26卷

关键词：

INTERFERENCE KNOCKDOWN; DSRNA; GENE; INFECTION; DELIVERY; PLANTS; NANOPARTICLES; SIRNA;

D O I：

10.1016/j.coviro.2017.07.009

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Exogenous application of double-stranded RNA (dsRNA) for virus resistance in plants represents a very attractive alternative to virus resistant transgenic crops or pesticides targeting virus vectors. However, the instability of dsRNA sprayed onto plants is a major challenge as spraying naked dsRNA onto plants provides protection against homologous viruses for only 5 days. Innovative approaches, such as the use of nanoparticles as carriers of dsRNA for improved stability and sustained release, are emerging as key disruptive technologies. Knowledge is still limited about the mechanism of entry, transport and processing of exogenously applied dsRNA in plants. Cost of dsRNA and regulatory framework will be key influencers towards practical adoption of this technology.

引用

页码：49 / 55

页数：7

共 47 条

[1] Toll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis [J].