Compensation of spectral and RF errors in swept-source OCT for high extinction complex demodulation

被引:15
作者
Siddiqui, Meena [1 ,2 ,3 ]
Tozburun, Serhat [2 ,3 ]
Zhang, Ellen Ziyi [2 ,3 ]
Vakoc, Benjamin J. [1 ,2 ,3 ]
机构
[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[2] MGH, Wellman Ctr Photomed, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
OPTICAL COHERENCE TOMOGRAPHY; DEPTH-DEGENERACY; DOMAIN; PHASE;
D O I
10.1364/OE.23.005508
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We provide a framework for compensating errors within passive optical quadrature demodulation circuits used in swept-source optical coherence tomography (OCT). Quadrature demodulation allows for detection of both the real and imaginary components of an interference fringe, and this information separates signals from positive and negative depth spaces. To achieve a high extinction (similar to 60 dB) between these positive and negative signals, the demodulation error must be less than 0.1% in amplitude and phase. It is difficult to construct a system that achieves this low error across the wide spectral and RF bandwidths of high-speed swept-source systems. In a prior work, post-processing methods for removing residual spectral errors were described. Here, we identify the importance of a second class of errors originating in the RF domain, and present a comprehensive framework for compensating both spectral and RF errors. Using this framework, extinctions >60 dB are demonstrated. A stability analysis shows that calibration parameters associated with RF errors are accurate for many days, while those associated with spectral errors must be updated prior to each imaging session. Empirical procedures to derive both RF and spectral calibration parameters simultaneously and to update spectral calibration parameters are presented. These algorithms provide the basis for using passive optical quadrature demodulation circuits with high speed and wide-bandwidth swept-source OCT systems. (C) 2015 Optical Society of America
引用
收藏
页码:5508 / 5520
页数:13
相关论文
共 12 条
[1]   High speed full range complex spectral domain optical coherence tomography [J].
Götzinger, E ;
Pircher, M ;
Leitgeb, RA ;
Hitzenberger, CK .
OPTICS EXPRESS, 2005, 13 (02) :583-594
[2]   Phase-shifting algorithm to achieve high-speed long-depth-range probing by frequency-domain optical coherence tomography [J].
Leitgeb, RA ;
Hitzenberger, CK ;
Fercher, AF ;
Bajraszewski, T .
OPTICS LETTERS, 2003, 28 (22) :2201-2203
[3]   Instantaneous quadrature components or Jones vector retrieval using the Pancharatnam-Berry phase in frequency domain low-coherence interferometry [J].
Lippok, Norman ;
Coen, Stephane ;
Leonhardt, Rainer ;
Nielsen, Poul ;
Vanholsbeeck, Frederique .
OPTICS LETTERS, 2012, 37 (15) :3102-3104
[4]   Instantaneous complex conjugate resolved spectral domain and swept-source OCT using 3x3 fiber couplers [J].
Sarunic, MV ;
Choma, MA ;
Yang, CH ;
Izatt, JA .
OPTICS EXPRESS, 2005, 13 (03) :957-967
[5]   Complex spectral OCT in human eye imaging in vivo [J].
Targowski, P ;
Wojtkowski, M ;
Kowalczyk, A ;
Bajraszewski, T ;
Szkulmowski, M ;
Gorczynska, W .
OPTICS COMMUNICATIONS, 2004, 229 (1-6) :79-84
[6]   A rapid, dispersion-based wavelength-stepped and wavelength-swept laser for optical coherence tomography [J].
Tozburun, Serhat ;
Siddiqui, Meena ;
Vakoc, Benjamin J. .
OPTICS EXPRESS, 2014, 22 (03) :3414-3424
[7]   Elimination of depth degeneracy in optical frequency-domain imaging through polarization-based optical demodulation [J].
Vakoc, BJ ;
Yun, SH ;
Tearney, GJ ;
Bouma, BE .
OPTICS LETTERS, 2006, 31 (03) :362-364
[8]   Phase-resolved optical frequency domain imaging [J].
Vakoc, BJ ;
Yun, SH ;
de Boer, JF ;
Tearney, GJ ;
Bouma, BE .
OPTICS EXPRESS, 2005, 13 (14) :5483-5493
[9]   Full range complex spectral optical coherence tomography technique in eye imaging [J].
Wojtkowski, M ;
Kowalczyk, A ;
Leitgeb, R ;
Fercher, AF .
OPTICS LETTERS, 2002, 27 (16) :1415-1417
[10]   Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting [J].
Yun, SH ;
Tearney, GJ ;
de Boer, JF ;
Bouma, BE .
OPTICS EXPRESS, 2004, 12 (20) :4822-4828