Bronchiolitis and SARS-CoV-2

被引：16

作者：

Milani, Gregorio Paolo ^{[1
,2
]}

Bollati, Valentina ^{[2
]}

Ruggiero, Luca ^{[3
]}

Bosis, Samantha ^{[3
]}

Pinzani, Raffaella Maria ^{[3
]}

Lunghi, Giovanna ^{[4
]}

Rota, Federica ^{[2
]}

Dioni, Laura ^{[2
]}

Luganini, Anna ^{[5
]}

Agostoni, Carlo ^{[2
,6
]}

Marchisio, Paola ^{[3
,7
]}

机构：

[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Unit, Milan, Lombardia, Italy

[2] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Lombardia, Italy

[3] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Highly Intens Care Unit, Milan, Lombardia, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Microbiol & Virol Unit, Milan, Italy

[5] Univ Turin, Turin, Piemonte, Italy

[6] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Pediat Unit, Milan, Lombardia, Italy

[7] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2021年 / 106卷 / 10期

关键词：

virology; epidemiology; COVID-19;

D O I：

10.1136/archdischild-2020-321108

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background It has been speculated that the SARS-CoV-2 was already widespread in western countries before February 2020. Methods We gauged this hypothesis by analysing the nasal swab of infants with either bronchiolitis or a non-infectious disease admitted to the Ospedale Maggiore, Milan (one of the first epicentres of SARS-CoV-2 outbreak in Europe) from November 2019. Results The SARS-CoV-2 RNA was never detected in 218 infants with bronchiolitis (95 females, median age 4.9 months) and 49 infants (22 females, median age 5.6 months) with a non-infectious disease between November 2019 and February 2020. On the contrary, two infants hospitalised for bronchiolitis between March and April 2020 tested positive for SARS-CoV-2. Conclusions This study does not support the hypothesis that SARS-CoV-2 was already circulating among infants before the official outbreak of SARS-CoV-2 infection. However, it shows for the first time that SARS-CoV-2 might cause bronchiolitis requiring hospitalisation.

引用

页码：999 / 1001

页数：3

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