New access to chiral pyrrolidine and piperidine β-enamino ketones.: Application to the enantioselective synthesis of (-)-hygroline

被引：6

作者：

Vanucci-Bacque, Corinne ^{[1
]}

Calvet-Vitale, Sandrine ^{[1
]}

Fargeau-Bellassoued, Marie-Claude ^{[1
]}

Lhommet, Gerard ^{[1
]}

机构：

[1] Univ Paris 06, Inst Chim Mol FR 2769, Chim Organ Lab, Equipe Chim Heterocycles,UMR 7611, 4 Pl Jussieu, F-75252 Paris 05, France

来源：

ARKIVOC | 2007年

关键词：

beta-enamino ketone; pyrrolidine; piperidine; hygroline;

D O I：

10.3998/ark.5550190.0008.f15

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report here a new access to chiral pyrrolidine and piperidine beta-enamino ketones by condensation of (S)-phenylglycinol omega-oxo alkynones. As an illustration of the synthetic potential of the target compounds, the total enantioselective synthesis of alkaloid (-)-hygroline was achieved.

引用

页码：148 / 161

页数：14

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