RNA N6-Methyladenosine Modifications and the Immune Response

被引：24

作者：

Wang, Ya-Nan ^{[1
]}

Yu, Chen-Yang ^{[1
]}

Jin, Hong-Zhong ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Dept Dermatol, Peking Union Med Coll Hosp, Beijing, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2020年 / 2020卷

关键词：

SINGLE-NUCLEOTIDE-RESOLUTION; TOLL-LIKE RECEPTORS; MESSENGER-RNA; GENE-EXPRESSION; MOLECULAR-BASIS; METHYLATION; N6-METHYLADENOSINE; METHYLTRANSFERASE; RECOGNITION; PROTEIN;

D O I：

10.1155/2020/6327614

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

N-6-methyladenosine (m(6)A) is the most important modification of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) in higher eukaryotes. Modulation of m(6)A modifications relies on methyltransferases and demethylases. The discovery of binding proteins confirms that the m(6)A modification has a wide range of biological effects and significance at the molecular, cellular, and physiological levels. In recent years, techniques for investigating m(6)A modifications of RNA have developed rapidly. This article reviews the biological significance of RNA m(6)A modifications in the innate immune response, adaptive immune response, and viral infection.

引用

页数：6

共 66 条

[1]

ADLER M, 1958, J BIOL CHEM, V230, P717

[2] HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events [J].

Alarcon, Claudio R. ;

Goodarzi, Hani ;

Lee, Hyeseung ;

Liu, Xuhang ;

Tavazoie, Saeed ;

Tavazoie, Sohail F. .

CELL, 2015, 162 (06) :1299-1308

[3] m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells [J].

Batista, Pedro J. ;

Molinie, Benoit ;

Wang, Jinkai ;

Qu, Kun ;

Zhang, Jiajing ;

Li, Lingjie ;

Bouley, Donna M. ;

Lujan, Ernesto ;

Haddad, Bahareh ;

Daneshvar, Kaveh ;

Carter, Ava C. ;

Flynn, Ryan A. ;

Zhou, Chan ;

Lim, Kok-Seong ;

Dedon, Peter ;

Wernig, Marius ;

Mullen, Alan C. ;

Xing, Yi ;

Giallourakis, Cosmas C. ;

Chang, Howard Y. .

CELL STEM CELL, 2014, 15 (06) :707-719

[4] A dynamic reversible RNA N6-methyladenosine modification: current status and perspectives [J].

Bi, Zhen ;

Liu, Youhua ;

Zhao, Yuanling ;

Yao, Yongxi ;

Wu, Ruifan ;

Liu, Qing ;

Wang, Yizhen ;

Wang, Xinxia .

JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) :7948-7956

[5]

BOKAR JA, 1994, J BIOL CHEM, V269, P17697

[6] Wilms' Tumor 1 as a Novel Target for lmmunotherapy of Leukemia [J].

Casalegno-Garduno, R. ;

Schmitt, A. ;

Wang, X. ;

Xu, X. ;

Schmitt, M. .

TRANSPLANTATION PROCEEDINGS, 2010, 42 (08) :3309-3311

[7] Dopamine Agonists Upregulate IL-6 and IL-8 Production in Human Keratinocytes [J].

Cecilia Parrado, Andrea ;

Canellada, Andrea ;

Gentile, Teresa ;

Beatriz Rey-Roldan, Estela .

NEUROIMMUNOMODULATION, 2012, 19 (06) :359-366

[8] m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency [J].

Chen, Tong ;

Hao, Ya-Juan ;

Zhang, Ying ;

Li, Miao-Miao ;

Wang, Meng ;

Han, Weifang ;

Wu, Yongsheng ;

Lv, Ying ;

Hao, Jie ;

Wang, Libin ;

Li, Ang ;

Yang, Ying ;

Jin, Kang-Xuan ;

Zhao, Xu ;

Li, Yuhuan ;

Ping, Xiao-Li ;

Lai, Wei-Yi ;

Wu, Li-Gang ;

Jiang, Guibin ;

Wang, Hai-Lin ;

Sang, Lisi ;

Wang, Xiu-Jie ;

Yang, Yun-Gui ;

Zhou, Qi .

CELL STEM CELL, 2015, 16 (03) :289-301

[9] Overexpression of Fto leads to increased food intake and results in obesity [J].

Church, Chris ;

Moir, Lee ;

McMurray, Fiona ;

Girard, Christophe ;

Banks, Gareth T. ;

Teboul, Lydia ;

Wells, Sara ;

Bruening, Jens C. ;

Nolan, Patrick M. ;

Ashcroft, Frances M. ;

Cox, Roger D. .

NATURE GENETICS, 2010, 42 (12) :1086-U147

[10] Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication [J].

Courtney, David G. ;

Kennedy, Edward M. ;

Dumm, Rebekah E. ;

Bogerd, Hal P. ;

Tsai, Kevin ;

Heaton, Nicholas S. ;

Cullen, Bryan R. .

CELL HOST & MICROBE, 2017, 22 (03) :377-+

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