Low-dose exposure to Bisphenol A during development has limited effects on male reproduction in midpubertal and aging Fischer 344 rats

被引：12

作者：

Sporndly-Nees, Ellinor ^{[1
]}

Boberg, Julie ^{[2
]}

Ekstedt, Elisabeth ^{[1
]}

Holm, Lena ^{[1
]}

Fakhrzadeh, Azadeh ^{[3
]}

Dunder, Linda ^{[4
]}

Kushnir, Mark M. ^{[5
,6
]}

Lejonklou, Margareta H. ^{[4
]}

Lind, P. Monica ^{[4
]}

机构：

[1] Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Box 7011, S-75007 Uppsala, Sweden

[2] Tech Univ Denmark, Div Diet Dis Prevent & Toxicol, Bldg 202, DK-2800 Lyngby, Denmark

[3] Iranian Res Inst Informat Sci & Technol IranDoc T, 1090 Enghelab, Tehran, Iran

[4] Uppsala Univ, Dept Med Sci Occupat & Environm Med, Akad Sjukhuset, S-75185 Uppsala, Sweden

[5] ARUP Inst Clin & Expt Pathol, Salt Lake City, UT 84108 USA

[6] Univ Utah, Dept Pathol, Salt Lake City, UT USA

来源：

REPRODUCTIVE TOXICOLOGY | 2018年 / 81卷

基金：

瑞典研究理事会;

关键词：

Bisphenol A; Developmental exposure; Low dose; Male reproduction; Puberty; Aging; Histopathology; Endocrine disrupting chemical; MASS-SPECTROMETRY ASSAY; ESTROGENIC CHEMICALS; SEXUAL DEVELOPMENT; POSITIVE CONTROLS; IN-UTERO; ESTRADIOL; TOXICITY; PROSTATE; MOUSE; METABOLISM;

D O I：

10.1016/j.reprotox.2018.08.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Low doses of Bisphenol A (BPA) during development may affect reproduction. In this study, Fischer 344 rats were exposed to 0.5 or 50 mu g BPA/kg bw/day via drinking water from gestational day 3.5 to postnatal day 22. Anogenital distance, organ weight, histopathology of reproductive organs, hormone analysis and sperm morphology were evaluated in male offspring. In this study no major effects of BPA on male reproduction in mid-pubertal (postnatal day 35) or adult (12-month-old) rats were revealed, apart from a higher prevalence of mild inflammatory cell infiltrate in cauda epididymis in adult rats exposed to 50 mu g BPA/kg bw/day. No BPA-related effects on sexual development were seen but care should be taken when evaluating histopathology in midpuberty testis due to large morphological variation. Results from the present study show no major signs of altered male reproduction in rats exposed to low doses of BPA during gestation and lactation.

引用

页码：196 / 206

页数：11

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