Biodistribution of 111In-DTPA-D-Phe1-octreotide in tumor-bearing nude mice:: influence of amount injected and route of administration

In nude mice carrying the human carcionoid GOT1 different amounts of In-111-DTPA-Phe(1)-octreotide and routes of administration were studied in relation to uptake in tumor and normal organs. The relative organ uptake varied with given amount; highest in tumor after 0.1 and 1 mug and lowest in muscle, heart and blood after 0.1 mug. The uptake decreased in lungs and spleen with higher amounts of In-111-DTPA-Phe1-octreotide. In all organs studied the tumor-to-normal-tissue activity concentration ratio was maximal at 0.1 and 1 mug, but route of administration influenced the uptake only little. (C) 2003 Elsevier Science Inc. All rights reserved.