6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine

被引：4

作者：

Asquith, Christopher R. M. ^{[1
,2
]}

Tizzard, Graham J. ^{[3
]}

机构：

[1] Univ North Carolina Chapel Hill, Dept Pharmacol, Sch Med, Chapel Hill, NC 27599 USA

[2] Univ North Carolina Chapel Hill, Struct Genom Consortium, UNC Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

[3] Univ Southampton, Sch Chem, UK Natl Crystallog Serv, Highfield Campus, Southampton SO17 1BJ, Hants, England

来源：

MOLBANK | 2019年 / 2019卷 / 04期

基金：

加拿大创新基金会; 巴西圣保罗研究基金会;

关键词：

2-methyl-2H-1,2,3-triazole; 4-anilino-quin(az)olines; conformational flexibility; hinge binder; kinase inhibitor design; IDENTIFICATION; RIVER; 1,2,3-TRIAZOLES; INHIBITORS; MUTAGEN; AICHI;

D O I：

10.3390/M1087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation. We also performed routine characterization with H-1/C-13-NMR and liquid chromatography (LC) and high-resolution mass spectra (HRMS).

引用

页数：6

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