Degeneration of the intervertebral disc with new approaches for treating low back pain

被引：3

作者：

Le Maitre, C. L. ^{[1
]}

Binch, A. L. A. ^{[1
]}

Thorpe, A. A. ^{[1
]}

Hughes, S. P. F. ^{[2
]}

机构：

[1] Sheffield Hallam Univ, Biomed Res Ctr, Sheffield S1 1WB, S Yorkshire, England

[2] Univ London Imperial Coll Sci Technol & Med, Orthopaed Surg, London, England

来源：

JOURNAL OF NEUROSURGICAL SCIENCES | 2015年 / 59卷 / 01期

关键词：

Intervertebral disc; Stem cells; Spinal fusion; Low back pain; NUCLEUS PULPOSUS CELLS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; FIBROBLAST-GROWTH-FACTOR; END-PLATE CHONDROCYTES; MESENCHYMAL STEM-CELLS; TUMOR-NECROSIS-FACTOR; HUMAN GENE-THERAPY; IN-VITRO; POTTS-DISEASE; LUMBAR SPINE;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review paper discusses the process of disc degeneration and the current understanding of cellular degradation in patients who present with low back pain. The role of surgical treatment for low back pain is analysed with emphasis on the proven value of spinal fusion. The interesting and novel developments of stem cell research in the treatment of low back pain are presented with special emphasis on the importance of the cartilaginous end plate and the role of IL-1 in future treatment modalities.

引用

页码：47 / 61

页数：15

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