Effect of lithium on the melatonin production in the pineal gland of viscacha

被引：1
|
作者：
Fuentes, Lucia B. [1 ]
Calderon, Claudia P. [1 ]
Aseff, Susana B. Garcia [1 ]
Munoz, Estela M. [2 ]
Moller, Morten [3 ]
Pelzer, Lilian E. [1 ]
机构：
[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, RA-5700 San Luis, Argentina
[2] Consejo Nacl Invest Cient & Tecn, Inst Histol & Embriol IHEM, Mendoza, Argentina
[3] Inst Med Anat, Copenhagen, Denmark
来源：
BIOLOGICAL RHYTHM RESEARCH | 2008年 / 39卷 / 01期
关键词：
lithium; melatonin; AA-NAT; HIOMT; pineal gland; viscacha;
D O I：
10.1080/09291010701292086
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Melatonin is synthesized primarily in the pineal gland. Lithium affects the circadian rhythms that may explain its therapeutic effectiveness in the treatment of bipolar disorder. The objective of this study was to investigate the effect of lithium on the biochemical parameters involved in melatonin synthesis in the pineal gland of viscacha. Viscachas were daily intraperitoneally injected with lithium chloride or saline solution for one month. Pineal mRNAs encoding 1-adrenoceptor and arylalkylamine-N-acetyltransferase enzyme (AA-NAT) were studied by in situ hybridization. Pineal melatonin concentrations were determined by radioimmunoassay, and AA-NAT and hydroxyindol-O-methyltransferase (HIOMT) activities were investigated by radiometric assays. The only parameters that decreased significantly were the expression of AA-NAT mRNA and pineal melatonin levels. Our data suggest that lithium treatment may decrease melatonin synthesis in the viscacha pineal gland by a complex mechanism that involves currently unknown events that are beyond a decrease in the expression of AA-NAT enzyme.
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收藏
页码：43 / 55
页数：13
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