Biocatalytic synthesis of quinoline derivatives via α-amylase catalysed one-pot domino aza-Michael/Aldol/aromatization reactions

被引：7
|
作者：
Dutt, Sunil [1 ]
Tyagi, Vikas [1 ]
机构：
[1] Thapar Inst Engn & Technol, Sch Chem & Biochem, Patiala 147004, Punjab, India
来源：
TETRAHEDRON LETTERS | 2021年 / 87卷
关键词：
Biocatalyst; alpha-Amylase; Cascade reactions; Aza-Michael; Aldol reaction; MICHAEL/ALDOL REACTION; ENANTIOSELECTIVE SYNTHESIS; FRIEDLANDER SYNTHESIS; CASCADE REACTIONS; CONSTRUCTION; HYDROLASES;
D O I：
10.1016/j.tetlet.2021.153527
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Quinoline moiety is a part of various drug molecules and natural products. Previously, a number of catalysts have been made available to synthesize substituted quinolines. Herein, we are reporting alpha-amylase catalysed synthesis of substituted quinolines via one-pot domino aza-Michael/Aldol/aromatization reactions. Moreover, the alpha-amylase enzyme from Aspergillus oryzae was found to catalyse the cascade reaction of various 2-aminobenzaldehydes with alpha, beta-unsaturated carbonyls in high catalytic efficiency (56-86% yield). (C) 2021 Elsevier Ltd. All rights reserved.
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页数：6
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