Practical considerations in enhancing LC-MS sensitivity for therapeutic protein bioanalysis

被引：4
作者：
Zhou, Shaolian [1 ]
Vazvaei, Faye [2 ]
Ferrari, Luca [1 ]
Qu, Jun [3 ,4 ]
机构：
[1] Roche Innovat Ctr Basel, Roche Pharmaceut Res & Early Dev, Basel, Switzerland
[2] Roche Innovat Ctr New York, Roche Pharmaceut Res & Early Dev, New York, NY 10016 USA
[3] Univ Buffalo State Univ New York, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Buffalo, NY 14214 USA
[4] New York State Ctr Excellence Bioinformat & Life, Buffalo, NY 14203 USA
来源：
BIOANALYSIS | 2017年 / 9卷 / 18期
关键词：
LC-MS; protein bioanalysis; sensitivity; signature peptide; ORTHOGONAL ARRAY OPTIMIZATION; MASS-SPECTROMETRY; IN-DEPTH; QUANTIFICATION; PEPTIDES; ACCURATE; QUANTITATION; ANTIBODIES; LC/MS; SCALE;
D O I：
10.4155/bio-2017-4982
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：1353 / 1356
页数：4
相关论文
共 19 条
[11]   Applications of low-flow LC-SRM for the analysis of large molecules in pharmaceutical R&D [J].
Lassman, Michael E. ;
Fernandez-Metzler, Carmen .
BIOANALYSIS, 2014, 6 (13) :1859-1867
[12]   Targeted Quantitation of Proteins by Mass Spectrometry [J].
Liebler, Daniel C. ;
Zimmerman, Lisa J. .
BIOCHEMISTRY, 2013, 52 (22) :3797-3806
[13]   Enhancing electrospray ionization efficiency of peptides by derivatization [J].
Mirzaei, Hamid ;
Regnier, Fred .
ANALYTICAL CHEMISTRY, 2006, 78 (12) :4175-4183
[14]   Mass Spectrometry Based Targeted Protein Quantification: Methods and Applications [J].
Pan, Sheng ;
Aebersold, Ruedi ;
Chen, Ru ;
Rush, John ;
Goodlett, David R. ;
McIntosh, Martin W. ;
Zhang, Jing ;
Brentnall, Teresa A. .
JOURNAL OF PROTEOME RESEARCH, 2009, 8 (02) :787-797
[15]   Can LC-MS/MS and ligand-binding assays live in harmony for large-molecule bioanalysis? [J].
Papadimitriou, Apollon ;
Bansal, Surendra ;
Heinrich, Julia ;
Staack, Roland F. .
BIOANALYSIS, 2014, 6 (13) :1735-1737
[16]   QUALITATIVE AND QUANTITATIVE CHARACTERIZATION OF PROTEIN BIOTHERAPEUTICS WITH LIQUID CHROMATOGRAPHY MASS SPECTROMETRY [J].
Qu, Miao ;
An, Bo ;
Shen, Shichen ;
Zhang, Ming ;
Shen, Xiaomeng ;
Duan, Xiaotao ;
Balthasar, Joseph P. ;
Qu, Jun .
MASS SPECTROMETRY REVIEWS, 2017, 36 (06) :734-754
[17]   An IonStar Experimental Strategy for MS1 Ion Current-Based Quantification Using Ultrahigh-Field Orbitrap: Reproducible, In-Depth, and Accurate Protein Measurement in Large Cohorts [J].
Shen, Xiaomeng ;
Shen, Shichen ;
Li, Jun ;
Hu, Qiang ;
Nie, Lei ;
Tu, Chengjian ;
Wang, Xue ;
Orsburn, Benjamin ;
Wang, Jianmin ;
Qu, Jun .
JOURNAL OF PROTEOME RESEARCH, 2017, 16 (07) :2445-2456
[18]   Large-Scale, Ion-Current-Based Proteomics Investigation of Bronchoalveolar Lavage Fluid in Chronic Obstructive Pulmonary Disease Patients [J].
Tu, Chengjian ;
Mammen, Manoj Jacob ;
Li, Jun ;
Shen, Xiaomeng ;
Jiang, Xiaosheng ;
Hu, Qiang ;
Wang, Jianmin ;
Sethi, Sanjay ;
Qu, Jun .
JOURNAL OF PROTEOME RESEARCH, 2014, 13 (02) :627-639
[19]   N-Terminal Derivatization of Peptides with Isothiocyanate Analogues Promoting Edman-Type Cleavage and Enhancing Sensitivity in Electrospray Ionization Tandem Mass Spectrometry Analysis [J].
Wang, Dongxia ;
Fang, Sunan ;
Wohlhueter, Robert M. .
ANALYTICAL CHEMISTRY, 2009, 81 (05) :1893-1900
12