Stereoselective total synthesis of pachastrissamine (jaspine B)

被引：45
|
作者：
Passiniemi, Mikko [1 ]
Koskinen, Ari M. P. [1 ]
机构：
[1] Aalto Univ, Organ Chem Lab, FIN-02015 Espoo, Finland
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 06期
关键词：
natural products; enantio selective synthesis; pachastrissamine; cross metathesis; cyclization;
D O I：
10.1016/j.tetlet.2007.12.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A short total synthesis of the cytotoxic natural product pachastrissamine is described. The synthesis includes eight steps starting from Garner's aldehyde and proceeds in 20% overall yield. Pd(0)-mediated intramolecular cyclisation and Ru-mediated cross-metathesis are the key reactions in this sequence. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：980 / 983
页数：4
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