Autoantibodies in Sjogren's Syndrome

被引：135

作者：

Fayyaz, Anum ^{[1
,2
,3
]}

Kurien, Biji T. ^{[1
,2
,3
]}

Scofield, R. Hal ^{[1
,2
,3
]}

机构：

[1] Oklahoma Med Res Fdn, Arthrit & Clin Immunol Program, 825 Northeast,13th St, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Coll Med, 1000 N Lincoln Blvd, Oklahoma City, OK 73104 USA

[3] US Dept Vet Affairs Hosp, Med & Res Serv, 921 NE 13th St, Oklahoma City, OK 73104 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2016年 / 42卷 / 03期

关键词：

Sjogren's syndrome; Autoantibodies; Congenital heart block; CONGENITAL HEART-BLOCK; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CITRULLINATED PEPTIDE ANTIBODIES; ALPHA-FODRIN ANTIBODIES; ANTICENTROMERE ANTIBODIES; NEONATAL LUPUS; CLINICAL-SIGNIFICANCE; RHEUMATOID-FACTOR; ANTI-RO/SSA; CLASSIFICATION CRITERIA;

D O I：

10.1016/j.rdc.2016.03.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We compiled information on antibodies in Sjogren syndrome (SS), focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjogren. We discussed studies concerning the presence of antibodies predating clinical manifestations of disease. Studies in the future are required to ascertain the pathogenic mechanisms associated with these antibodies and the specific clinical manifestation related to new autoantibodies.

引用

页码：419 / +

页数：17

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