Efficient Multicomponent Reaction Synthesis of the Schistosomiasis Drug Praziquantel

被引：84

作者：

Cao, Haiping ^{[1
]}

Liu, Haixia ^{[1
]}

Doemling, Alexander ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Pharmaceut Sci & Chem, Pittsburgh, PA 15261 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 41期

关键词：

drug discovery; isocyanides; multicomponent reactions; Pictet-Spengler reaction; Ugi reaction; GENITAL SCHISTOSOMIASIS; ASSOCIATION; HIV;

D O I：

10.1002/chem.201002046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Shorter than ever: A convergent, efficient, and scalable access based on a key Ugi four-component reaction (4CR) followed by a Pictet-Spengler reaction comprises the shortest known synthesis to the schistosomiasis drug praziquantel (see scheme). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12296 / 12298

页数：3

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