Laser-Assisted Drug Delivery

被引：26

作者：

Zaleski-Larsen, Lisa Ann ^{[1
]}

Fabi, Sabrina G. ^{[2
]}

机构：

[1] Naval Med Ctr San Diego, Dept Dermatol, 34520 Bob Wilson Dr, San Diego, CA 92134 USA

[2] Cosmet Laser Dermatol, San Diego, CA USA

来源：

DERMATOLOGIC SURGERY | 2016年 / 42卷 / 08期

关键词：

ERBIUM-YAG LASER; TRANSDERMAL DELIVERY; FRACTIONAL LASER; 5-AMINOLEVULINIC ACID; STRATUM-CORNEUM; SKIN PERMEATION; ABLATION; ENHANCE; SCARS; PRETREATMENT;

D O I：

10.1097/DSS.0000000000000556

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

BACKGROUNDLaser-assisted drug delivery (LADD) is an evolving new therapy with many possible applications as a highly targeted customizable method for distribution of drugs within the skin. LADD offers the advantages of accessibility, noninvasiveness, compliance, safety, and effectiveness.OBJECTIVETo review the available literature regarding LADD.METHODSA MEDLINE search was performed on LADD from 1989 to 2015, and the results are summarized. Practical applications of these procedures are also discussed.RESULTSReports of the use of ablative, nonablative, and fractional lasers as a means to increase cutaneous permeation of the topical application of medications and cosmeceuticals were found. The focus of the review was to demonstrate the variety of topical treatments that have been used with the LADD method and the multitude of future studies needed to fully characterize the best application of this evolving technology.CONCLUSIONThe most comprehensive review in the literature to date on LADD is provided. Further studies are needed to fully evaluate the safety, dosing, side effects, and results.

引用

页码：919 / 931

页数：13

共 58 条

[1] Systemic exposure, tolerability, and efficacy of pimecrolimus cream 1% in atopic dermatitis patients [J].

Allen, BR ;

Lakhanpaul, M ;

Morris, A ;

Lateo, S ;

Davies, T ;

Scott, G ;

Cardno, M ;

Ebelin, ME ;

Burtin, P ;

Stephenson, TJ .

ARCHIVES OF DISEASE IN CHILDHOOD, 2003, 88 (11) :969-973

[2] Laser Treatment of Traumatic Scars With an Emphasis on Ablative Fractional Laser Resurfacing Consensus Report [J].

Anderson, R. Rox ;

Donelan, Matthias B. ;

Hivnor, Chad ;

Greeson, Eric ;

Ross, E. Victor ;

Shumaker, Peter R. ;

Uebelhoer, Nathan S. ;

Waibel, Jill S. .

JAMA DERMATOLOGY, 2014, 150 (02) :187-193

[3]

[Anonymous], 2009, DERM ABS PEST EV VAR

[4]

[Anonymous], 2006, EXCIPIENT DEV PHARM

[5] Effect of controlled laser microporation on drug transport kinetics into and across the skin [J].

Bachhav, Y. G. ;

Summer, S. ;

Heinrich, A. ;

Bragagna, T. ;

Boehler, C. ;

Kalia, Y. N. .

JOURNAL OF CONTROLLED RELEASE, 2010, 146 (01) :31-36

[6] Using laser microporation to improve transdermal delivery of diclofenac: Increasing bioavailability and the range of therapeutic applications [J].

Bachhav, Yogeshwar G. ;

Heinrich, Arne ;

Kalia, Yogeshvar N. .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2011, 78 (03) :408-414

[7] Laser-assisted penetration of topical anesthetic in adults [J].

Baron, ED ;

Harris, L ;

Redpath, WS ;

Shapiro, H ;

Hetzel, F ;

Morley, G ;

Bar-Or, D ;

Stevens, SR .

ARCHIVES OF DERMATOLOGY, 2003, 139 (10) :1288-1290

[8] Laser-assisted drug delivery: beyond ablative devices [J].

Bloom, B. S. .

BRITISH JOURNAL OF DERMATOLOGY, 2014, 170 (06) :1217-1218

[9] Ablative Fractional Resurfacing in Topical Drug Delivery: An Update and Outlook [J].

Bloom, Bradley S. ;

Brauer, Jeremy A. ;

Geronemus, Roy G. .

DERMATOLOGIC SURGERY, 2013, 39 (06) :839-848

[10] Convergence of anatomy, technology, and therapeutics: a review of laser-assisted drug delivery [J].

Brauer, Jeremy A. ;

Krakowski, Andrew C. ;

Bloom, Bradley S. ;

Nguyen, Tuyet A. ;

Geronemus, Roy G. .

SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 2014, 33 (04) :176-181

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