Substituent Control over Dimerization Affinity of Triply Hydrogen Bonded Heterodimers

被引：32

作者：

Gooch, Adam ^{[1
]}

McGhee, Andrea M. ^{[1
]}

Pellizzaro, Maria L. ^{[1
]}

Lindsay, Christopher I. ^{[3
]}

Wilson, Andrew J. ^{[1
,2
]}

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England

[3] Huntsman Polyurethanes, B-3078 Everberg, Belgium

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

ARRAYS; RECOGNITION; COMPLEXES; FIDELITY; CYTOSINE; DESIGN; UREAS;

D O I：

10.1021/ol102619u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Linear arrays of hydrogen bonds represent important elements of the supramolecular toolkit for receptor design, assembly of supramolecular polymers, and other well-defined supramolecular structures. It is illustrated that remote substituent effects control dimerization affinity in a predictable manner using a conformer independent ureidoimidazole DDA motif and its amidoisocytosine based AAD partner.

引用

页码：240 / 243

页数：4

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