Novel H5N6 avian influenza virus reassortants with European H5N8 isolated in migratory birds, China

被引：13

作者：

Sun, Jing ^{[1
]}

Zhao, Lu ^{[2
]}

Li, Xiang ^{[1
]}

Meng, Weiyue ^{[3
]}

Chu, Dong ^{[4
]}

Yang, Xiaoyu ^{[1
]}

Peng, Peng ^{[4
]}

Zhi, Min ^{[1
]}

Qin, Siyuan ^{[4
]}

Fu, Tian ^{[1
]}

Li, Jinghao ^{[4
]}

Lu, Shaoxia ^{[1
]}

Wang, Weidong ^{[5
]}

He, Xin ^{[5
]}

Yu, Mengqi ^{[5
]}

Lv, Xinru ^{[1
]}

Ma, Wenge ^{[1
]}

Liao, Mengying ^{[1
]}

Liu, Zhensheng ^{[1
,6
]}

Zhang, Guogang ^{[3
]}

Wang, Yulong ^{[1
]}

Li, Yanbing ^{[2
]}

Chai, Hongliang ^{[1
,6
]}

Lu, Jun ^{[3
]}

Hua, Yuping ^{[1
]}

机构：

[1] NE Forestry Univ, Coll Wildlife, Protected Area, Harbin, Peoples R China

[2] Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China

[3] Chinese Acad Forestry, Res Inst Forest Ecol, Environm, Beijing, Beijing, Peoples R China

[4] Gen Stn Surveillance Wildlife Dis & Wildlife Born, Natl Forestry, Grassland Adm, Shenyang, Peoples R China

[5] Monitoring Ctr Terr Wildlife Epidm Dis, Yinchuan, Peoples R China

[6] Grassland Adm, Key Lab Conservat Biol, Natl Forestry, Harbin, Peoples R China

来源：

TRANSBOUNDARY AND EMERGING DISEASES | 2020年 / 67卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Avian influenza virus; migratory birds; pathogenicity; phylogenetic; SINGLE-AMINO-ACID; WILD BIRDS; HEMAGGLUTININ; PROTEIN; PATHOGENICITY; GLYCOSYLATION; DETERMINANT; NETHERLANDS; NETWORKS; CLEAVAGE;

D O I：

10.1111/tbed.13380

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Five novel H5N6 influenza viruses, including four highly pathogenic avian influenza viruses and one low pathogenic avian influenza virus, were isolated from migratory birds in Ningxia, China, in November 2017. To understand the genetic origination of the novel H5N6 virus, and the infectivity and pathogenicity of the four highly pathogenic avian influenza viruses in mammals, phylogeographic analyses and infection studies in mice were performed. The phylogenetic and phylogeographic analyses showed that the H5N6 isolates, which are closely related to the viruses from Korea, Japan and the Netherlands, originated from reassortant virus between H5N8 and HxN6 viruses from western Russia. The animal study revealed that the SBD-87 isolate presented moderate virulence in mice, suggesting a potential public risk to humans and a potential threat to public health.

引用

页码：648 / 660

页数：13

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