A mechanism controlling the characteristics of T-wave alternans measurements in the setting of myocardial ischemia

被引:2
作者
Feldman, AB [1 ]
Esperer, HD [1 ]
Cohen, RJ [1 ]
机构
[1] Harvard Univ, MIT, Div HST, Cambridge, MA 02139 USA
来源
COMPUTERS IN CARDIOLOGY 1999, VOL 26 | 1999年 / 26卷
关键词
D O I
10.1109/CIC.1999.825928
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
T-Wave alternans (TWA) is a variation in the morphology of the T wave of the electrocardiogram (ECG) that repeats on an every other beat basis. In recent clinical studies, its presence has shown to be highly predictive of the occurrence of lethal ventricular arrhythmias. Measurements of TWA using power spectral analysis of the ECG signals have shown that the power at the alternans frequency (0.5 cycles per bear) increases with heart rate following onset at a patient-specific heart rare threshold. The mechanisms underlying these phenomena have not been fully established. In this paper, we report a mechanism that can account for these two phenomena in the setting of myocardial ischemia.
引用
收藏
页码:149 / 152
页数:4
相关论文
共 9 条
[1]   T wave alternans during exercise and atrial pacing in humans [J].
Hohnloser, SH ;
Klingenheben, T ;
Zabel, M ;
Li, YG ;
Albrecht, P ;
Cohen, RJ .
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 1997, 8 (09) :987-993
[2]  
KLEBER AG, 1990, CARDIAC ELECTROPHYSI, P174
[3]   ISCHEMIA-INDUCED ALTERNANS OF ACTION-POTENTIAL DURATION IN THE INTACT-HEART - DEPENDENCE ON CORONARY FLOW, PRELOAD AND CYCLE LENGTH [J].
KURZ, RW ;
MOHABIR, R ;
REN, XL ;
FRANZ, MR .
EUROPEAN HEART JOURNAL, 1993, 14 (10) :1410-1420
[4]   A MODEL OF THE VENTRICULAR CARDIAC ACTION-POTENTIAL - DEPOLARIZATION, REPOLARIZATION, AND THEIR INTERACTION [J].
LUO, CH ;
RUDY, Y .
CIRCULATION RESEARCH, 1991, 68 (06) :1501-1526
[5]  
MOHABIR R, 1990, CARDIAC ELECTROPHYSI, P448
[6]   ELECTRICAL ALTERNANS AND VULNERABILITY TO VENTRICULAR ARRHYTHMIAS [J].
ROSENBAUM, DS ;
JACKSON, LE ;
SMITH, JM ;
GARAN, H ;
RUSKIN, JN ;
COHEN, RJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (04) :235-241
[7]  
SHAW R, 1994, COMP CARDIOL, P641
[8]   ELECTROPHYSIOLOGIC BASIS FOR T-WAVE ALTERNANS AS AN INDEX OF VULNERABILITY TO VENTRICULAR-FIBRILLATION [J].
VERRIER, RL ;
NEARING, BD .
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 1994, 5 (05) :445-461
[9]   EFFECT OF EXTRACELLULAR PH ON SODIUM CURRENT IN ISOLATED, SINGLE-RAT VENTRICULAR CELLS [J].
YATANI, A ;
BROWN, AM ;
AKAIKE, N .
JOURNAL OF MEMBRANE BIOLOGY, 1984, 78 (02) :163-168