Interplay between SOX9 transcription factor and microRNAs in cancer

被引：47

作者：

Ashrafizadeh, Milad ^{[1
,2
]}

Zarrabi, Ali ^{[2
]}

Orouei, Sima ^{[3
]}

Zabolian, Amirhossein ^{[4
]}

Saleki, Hossein ^{[4
]}

Azami, Negar ^{[4
]}

Bejandi, Atefe Kazemzade ^{[4
]}

Mirzaei, Sepideh ^{[5
]}

Janaghard, Milad Nemati ^{[6
]}

Hushmandi, Kiavash ^{[7
]}

Nabavi, Noushin ^{[8
,9
]}

Baradaran, Behzad ^{[10
]}

Kumar, Alan Prem ^{[11
,12
,13
]}

Makvandi, Pooyan ^{[14
]}

Samarghandian, Saeed ^{[15
]}

Khan, Haroon ^{[16
]}

Hamblin, Michael R. ^{[17
]}

机构：

[1] Sabanci Univ, Fac Engn & Nat Sci, Univ Caddesi 27, TR-34956 Istanbul, Turkey

[2] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey

[3] Islamic Azad Univ, Dept Genet, Tehran Med Sci, Tehran, Iran

[4] Islamic Azad Univ, Tehran Med Sci, Young Researchers & Elite Club, Tehran, Iran

[5] Islamic Azad Univ, Dept Biol, Fac Sci, Sci & Res Branch, Tehran, Iran

[6] Islamic Azad Univ, Nursing & Midwifery Dept, Tehran Med Sci Branch, Tehran, Iran

[7] Univ Tehran, Dept Food Hyg & Qual Control, Div Epidemiol & Zoonoses, Fac Vet Med, Tehran, Iran

[8] Univ British Columbia, Dept Urol Sci, Vancouver, BC V6H 3Z6, Canada

[9] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H 3Z6, Canada

[10] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[11] Natl Univ Singapore, Yong Loo Lin Sch Med, Canc Sci Inst Singapore, Singapore 117599, Singapore

[12] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117599, Singapore

[13] Natl Univ Singapore, NUS Ctr Canc Res, Yong Loo Lin Sch Med, Singapore 117597, Singapore

[14] Ist Italiano Tecnol, Ctr Mat Interfaces, Wale Rinaldo Piaggio 34, I-56025 Pisa, Italy

[15] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran

[16] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan

[17] Univ Johannesburg, Laser Res Ctr, Fac Hlth Sci, ZA-2028 Doornfontein, South Africa

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2021年 / 183卷

基金：

新加坡国家研究基金会;

关键词：

SOX9; Transcription factor; MicroRNA; Cancer; Long non-coding RNA; Circular RNA; LONG NONCODING RNA; CELL LUNG-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; GASTRIC-CANCER; CERVICAL-CANCER; HEPATOCELLULAR-CARCINOMA; TUMOR-SUPPRESSOR; OVARIAN-CANCER; MIR-1-3P SUPPRESSES; SIGNALING PATHWAY;

D O I：

10.1016/j.ijbiomac.2021.04.185

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SOX transcription factors are critical regulators of development, homeostasis and disease progression and their dysregulation is a common finding in various cancers. SOX9 belongs to SOXE family located on chromosome 17. MicroRNAs (miRNAs) possess the capacity of regulating different transcription factors in cancer cells by binding to 3'-UFR. Since miRNAs can affect differentiation, migration, proliferation and other physiological mechanisms, disturbances in their expression have been associated with cancer development. In this review, we evaluate the relationship between miRNAs and SOX9 in different cancers to reveal how this interaction can affect proliferation, metastasis and therapy response of cancer cells. The tumor-suppressor miRNAs can decrease the expression of SOX9 by binding to the 3'-UTR of lnRNAs. Furthermore, the expression of downstream targets of SOX9, such as c-Myc, Wnt, PI3K/Akt can be affected by miRNAs. It is noteworthy that other non-coding RNAs including lncRNAs and circRNAs regulate miRNA/SOX9 expression to promote/inhibit cancer progression and malignancy. The pre-clinical findings can be applied as biomarkers for diagnosis and prognosis of cancer patients. (C) 2021 Elsevier B.V. All rights reserved.

引用

页码：681 / 694

页数：14

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