Brevican: A key proteoglycan in the perisynaptic extracellular matrix of the brain

被引：71

作者：

Frischknecht, Renato ^{[1
]}

Seidenbecher, Constanze I. ^{[1
]}

机构：

[1] Leibniz Inst Neurobiol, AG Perisynapt Extracellular Matrix, D-39118 Magdeburg, Germany

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 07期

关键词：

Extracellular matrix; Lecticans; Perisynaptic matrix; Neuronal plasticity; Metalloproteinases; CHONDROITIN SULFATE PROTEOGLYCAN; ENRICHED HYALURONAN-BINDING; PERINEURONAL NETS; PROTEOLYTIC CLEAVAGE; VERSICAN; GLIOMA; NEUROCAN; FAMILY; ASSOCIATION; EXPRESSION;

D O I：

10.1016/j.biocel.2012.03.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brevican is a neural proteoglycan implicated in a multitude of physiological and pathophysiological plasticity processes in the brain. It localizes to neuronal surfaces and contributes to the formation of specific types of extracellular matrix like the perineuronal nets or the perisynaptic or axon initial segment-based matrix in mature neuronal tissue. Via a variable degree of chondroitin sulfate attachment, limited proteolytic cleavage by matrix metalloproteinases, differential splicing and Ca2+-dependent binding to interaction partners it acts as a regulator in synaptic plasticity, glioma invasion, post-lesion plasticity or Alzheimer's disease. This review briefly summarizes its gene and protein structure, biochemical interactions and neurobiological functions. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1051 / 1054

页数：4

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