Brain-Targeted Biomimetic Nanodecoys with Neuroprotective Effects for Precise Therapy of Parkinson's Disease

被引：53

作者：

Liu, Yao ^{[1
]}

Luo, Jingshan ^{[1
]}

Liu, Yujing ^{[1
]}

Liu, Wen ^{[2
]}

Yu, Guangtao ^{[3
]}

Huang, Yuting ^{[4
]}

Yang, Yu ^{[4
]}

Chen, Xiaojia ^{[2
]}

Chen, Tongkai ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou 510405, Peoples R China

[2] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China

[3] Southern Med Univ, Stomatol Hosp, Guangzhou 510280, Peoples R China

[4] Shanghai Jiao Tong Univ, Renji Hosp, Inst Mol Med IMM, Sch Med, Shanghai 200240, Peoples R China

来源：

ACS CENTRAL SCIENCE | 2022年 / 8卷 / 09期

基金：

中国国家自然科学基金;

关键词：

ALPHA-SYNUCLEIN; CURCUMIN; NANOPARTICLES; DELIVERY; MODEL;

D O I：

10.1021/acscentsci.2c00741

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra and the accumulation of alpha-synuclein aggregates called Lewy bodies. Here, nanodecoys were designed from a rabies virus polypeptide with a 29 amino acid (RVG29)-modified red blood cell membrane (RBCm) to encapsulate curcumin nanocrystals (Cur-NCs), which could effectively protect dopaminergic neurons. The RVG29-RBCm/Cur-NCs nanodecoys effectively escaped from retic-uloendothelial system (RES) uptake, enabled prolonged blood circulation, and enhanced blood-brain barrier (BBB) crossing after systemic administration. Cur-NCs loaded inside the nanodecoys exhibited the recovery of dopamine levels, inhibition of alpha-synuclein aggregation, and reversal of mitochondrial dysfunction in PD mice. These findings indicate the promising potential of biomimetic nanodecoys in treating PD and other neurodegenerative diseases.

引用

页码：1336 / 1349

页数：14

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