T cells in the pathogenesis of systemic lupus erythematosus

被引:33
作者
Hoffman, RW
机构
[1] Univ Missouri, Div Rheumatol & Immunol, Columbia, MO 65212 USA
[2] Dept Vet Affairs Med Ctr, Columbia, MO USA
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2001年 / 6卷
关键词
systemic lupus erythematosus; human; autoimmune; T lymphocyte; small nuclear ribonucleoprotein; mixed connective tissue disease; T cell receptor; review;
D O I
10.2741/Hoffman
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The role of T cells in the pathogenesis of systemic lupus erythematosus (SLE) is reviewed with a focus on autoantigen-specific T cells in SLE. The initial clue to a role for T cells in SLE was histopathologic studies demonstrating extensive infiltration of T cells at the sites of inflammation. Later studies, showing association between HLA polymorphisms and specific autoantibodies, directly implicated a role for T cells in autoantibody production. More recently, we and others have identified and characterized autoantigen-specific T cells in SLE. We review these studies on the role of autoantigen-specific T cells in SLE and present new findings on the molecular characterization of T cell immunity to Sm-B, Sm-D and U1-70kD small nuclear ribonucleoprotein (snRNP) autoantigens.
引用
收藏
页码:D1369 / D1378
页数:10
相关论文
共 66 条
  • [1] INTERRELATIONSHIPS OF HLA-DR, MB, AND MT PHENOTYPES, AUTOANTIBODY EXPRESSION, AND CLINICAL-FEATURES IN SYSTEMIC LUPUS-ERYTHEMATOSUS
    AHEARN, JM
    PROVOST, TT
    DORSCH, CA
    STEVENS, MB
    BIAS, WB
    ARNETT, FC
    [J]. ARTHRITIS AND RHEUMATISM, 1982, 25 (09): : 1031 - 1040
  • [2] RELATIONSHIPS OF HLA-DR AND MT ANTIGENS TO AUTOANTIBODY EXPRESSION IN SYSTEMIC LUPUS-ERYTHEMATOSUS
    ALVARELLOS, A
    AHEARN, JM
    PROVOST, TT
    DORSCH, CA
    STEVENS, MB
    BIAS, WB
    ARNETT, FC
    [J]. ARTHRITIS AND RHEUMATISM, 1983, 26 (12): : 1533 - 1535
  • [3] Apoptosis in systemic lupus erythematosus - Clinical implications
    Andrade, F
    Casciola-Rosen, L
    Rosen, A
    [J]. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 2000, 26 (02) : 215 - +
  • [4] BILLINGS PB, 1983, J IMMUNOL, V131, P347
  • [5] AUTOANTIGENS TARGETED IN SYSTEMIC LUPUS-ERYTHEMATOSUS ARE CLUSTERED IN 2 POPULATIONS OF SURFACE-STRUCTURES ON APOPTOTIC KERATINOCYTES
    CASCIOLAROSEN, LA
    ANHALT, G
    ROSEN, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (04) : 1317 - 1330
  • [6] STRUCTURE AND SPECIFICITY OF T-CELL RECEPTORS EXPRESSED BY POTENTIALLY PATHOGENIC ANTI-DNA AUTOANTIBODY-INDUCING T-CELLS IN HUMAN LUPUS
    DESAIMEHTA, A
    MAO, CC
    RAJAGOPALAN, S
    ROBINSON, T
    DATTA, SK
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) : 531 - 541
  • [7] Critical self-epitopes are key to the understanding of self-tolerance and autoimmunity
    Dighiero, G
    Rose, NR
    [J]. IMMUNOLOGY TODAY, 1999, 20 (09): : 423 - 428
  • [8] FENNING S, 1995, CLIN EXP IMMUNOL, V101, P408
  • [9] Multiple protein:protein interactions between the snRNP common core proteins
    Fury, MG
    Zhang, W
    Christodoulopoulos, I
    Zieve, GW
    [J]. EXPERIMENTAL CELL RESEARCH, 1997, 237 (01) : 63 - 69
  • [10] HLA-DR4 AND GM(1,3-5,21) ARE ASSOCIATED WITH U1-NRNP ANTIBODY POSITIVE CONNECTIVE-TISSUE DISEASE
    GENTH, E
    ZARNOWSKI, H
    MIERAU, R
    WOHLTMANN, D
    HARTL, PW
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 1987, 46 (03) : 189 - 196