Three-dimensionally-patterned submicrometer-scale hydrogel/air networks that offer a new platform for biomedical applications

被引：34

作者：

Jang, Ji-Hyun ^{[3
]}

Jhaveri, Shalin J. ^{[1
,2
]}

Rasin, Boris ^{[3
]}

Koh, ChoengYang ^{[3
]}

Ober, Christopher K. ^{[1
]}

Thomas, Edwin L. ^{[3
]}

机构：

[1] Cornell Univ, Dept Mat Sci & Engn, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

[3] MIT, Dept Mat Sci & Engn, Inst Soldier Nanotechnol, Cambridge, MA 02139 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 05期

关键词：

D O I：

10.1021/nl080444+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phase mask interference lithography was employed to fabricate three-dimensional (3D) hydrogel structures with high surface area on neural prosthetic devices. A random terpolymer of poly(hydroxyethyl methacrylate-ran-methyl methacrylate-ran-methacrylic acid) was synthesized and used as a negative-tone photoresist to generate bicontinuous 3D hydrogel structures at the submicrometer scale. We demonstrated that the fully open 3D hydrogel/air networks can be used as a pH-responsive polymeric drug-release system for the delivery of neurotrophins to enhance the performance of neural prosthetic devices. Additionally an open hydrogel structure will provide direct access of neuronal growth to the device for improved electrical coupling.

引用

页码：1456 / 1460

页数：5