Diastereoselective syntheses of chroman spiroketals via [4+2] cycloaddition of enol ethers and o-quinone methides

被引：91

作者：

Marsini, Maurice A. ^{[1
]}

Huang, Yaodong ^{[1
]}

Lindsey, Christopher C. ^{[1
]}

Wu, Kun-Liang ^{[1
]}

Pettus, Thomas R. R. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 07期

关键词：

D O I：

10.1021/ol8003244

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of chroman spiroketals are synthesized via inverse-demand [4 + 2] cycloaddition of enol ethers and ortho-quinone methides (o-QMs). Low temperature o-QM generation in situ allows for the kinetic, diastereoselective construction of these motifs, providing entry to a number of unusual chroman spiroketal natural products.

引用

页码：1477 / 1480

页数：4

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