13C labeling indicates that the epoxide-containing amino acid of HC-toxin is biosynthesized by head-to-tail condensation of acetate

被引：5

作者：

Cheng, YQ

Le, LD

Walton, JD ^{[1
]}

Bishop, KD

机构：

[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Energy, Plant Res Lab, E Lansing, MI 48824 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np980209e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

HC-toxin, cyclo(D-Prb-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid, is a potent inhibitor of histone deacetylase. Previous molecular genetic studies indicated that HC-toxin biosynthesis requires a dedicated fatty acid synthase. The incorporation of [C-13]acetate into HC-toxin was studied using NMR. The pattern of incorporation of C-13 was consistent with the carbons of Aeo being derived from head-to-tail condensation of acetate.

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页码：143 / 145

页数：3

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