Sex differences in the prevalence and prognostic impact of physical frailty and sarcopenia among older patients with heart failure

被引：18

作者：

Maeda, Daichi ^{[1
,2
]}

Matsue, Yuya ^{[1
,3
]}

Kagiyama, Nobuyuki ^{[4
,5
,6
]}

Jujo, Kentaro ^{[7
]}

Saito, Kazuya ^{[8
]}

Kamiya, Kentaro ^{[9
]}

Saito, Hiroshi ^{[1
,10
]}

Ogasahara, Yuki ^{[11
]}

Maekawa, Emi ^{[12
]}

Konishi, Masaaki ^{[13
]}

Kitai, Takeshi ^{[14
,15
]}

Iwata, Kentaro ^{[15
]}

Wada, Hiroshi ^{[16
]}

Hiki, Masaru ^{[1
]}

Dotare, Taishi ^{[1
]}

Sunayama, Tsutomu ^{[1
]}

Kasai, Takatoshi ^{[1
]}

Nagamatsu, Hirofumi ^{[17
]}

Ozawa, Tetsuya ^{[18
]}

Izawa, Katsuya ^{[19
]}

Yamamoto, Shuhei ^{[20
]}

Aizawa, Naoki ^{[21
]}

Wakaume, Kazuki ^{[22
]}

Oka, Kazuhiro ^{[23
]}

Momomura, Shin-ichi ^{[24
]}

Minamino, Tohru ^{[1
,25
,26
]}

机构：

[1] Juntendo Univ, Dept Cardiovasc Biol & Med, Grad Sch Med, Tokyo, Japan

[2] Osaka Med & Pharmaceut Univ, Dept Cardiol, Takatsuki, Osaka, Japan

[3] Juntendo Univ, Cardiovasc Resp Sleep Med, Grad Sch Med, Tokyo, Japan

[4] Sakakibara Heart Inst Okayama, Dept Cardiol, Okayama, Japan

[5] Juntendo Univ, Dept Digital Hlth & Telemedicine R&D, Tokyo, Japan

[6] Juntendo Univ, Dept Cardiovasc Biol & Med, Fac Med, Tokyo, Japan

[7] Juntendo Univ, Dept Cardiovasc Biol & Med, Fac Med, Tokyo, Japan

[8] Nishiarai Heart Ctr Hosp, Dept Cardiol, Tokyo, Japan

[9] Sakakibara Heart Inst Okayama, Dept Rehabil, Okayama, Japan

[10] Kitasato Univ, Sch Allied Hlth Sci, Dept Rehabil, Sagamihara, Kanagawa, Japan

[11] Kameda Med Ctr, Dept Rehabil, Kamogawa, Japan

[12] Sakakibara Heart Inst Okayama, Dept Nursing, Okayama, Japan

[13] Kitasato Univ, Dept Cardiovasc Med, Sch Med, Sagamihara, Kanagawa, Japan

[14] Yokohama City Univ, Div Cardiol, Med Ctr, Yokohama, Kanagawa, Japan

[15] Natl Cerebral & Cardiovasc Ctr, Dept Cardiovasc Med, Osaka, Japan

[16] Kobe City Med Ctr Gen Hosp, Dept Rehabil, Kobe, Hyogo, Japan

[17] Jichi Med Univ, Saitama Med Ctr, Dept Cardiovasc Med, Saitama, Japan

[18] Tokai Univ, Dept Cardiol, Sch Me, Isehara, Kanagawa, Japan

[19] Odawara Municipal Hosp, Dept Rehabil, Odawara, Japan

[20] Kasukabe Chuo Gen Hosp, Dept Rehabil, Kasukabe, Japan

[21] Shinshu Univ Hosp, Dept Rehabil, Matsumoto, Nagano, Japan

[22] Univ Ryukyus, Dept Cardiovasc Med Nephrol & Neurol, Okinawa, Japan

[23] Kitasato Univ, Rehabil Ctr, Med Ctr, Kitamoto, Japan

[24] Saitama Citizens Med Ctr, Dept Rehabil, Saitama, Japan

[25] Saitama Citizens Med Ctr, Saitama, Japan

[26] Japan Agcy Med Res & Dev, Japan Agcy Med Res & Dev Core Res Evolutionary Me, Tokyo, Japan

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2022年 / 32卷 / 02期

关键词：

Heart failure; Frailty; Sarcopenia; Sex characteristics; Prognosis; PRESERVED EJECTION FRACTION; CONSENSUS; SURVIVAL;

D O I：

10.1016/j.numecd.2021.10.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: Frailty and sarcopenia are common and confer poor prognosis in elderly patients with heart failure; however, gender differences in its prevalence or prognostic impact remain unclear. Methods and results: We included 1332 patients aged >65 years, who were hospitalized for heart failure. Frailty and sarcopenia were defined using the Fried phenotype model and Asian Working Group for Sarcopenia criteria, respectively. Gender differences in frailty and sarcopenia, and interactions between sex and prognostic impact of frailty/sarcopenia on 1-year mortality were evaluated. Overall, 53.9% men and 61.0% women and 23.7% men and 14.0% women had frailty and sarcopenia, respectively. Although sarcopenia was more prevalent in men, no gender differences existed in frailty after adjusting for age. On Kaplan-Meier analysis, frailty and sarcopenia were significantly associated with 1-year mortality in both sexes. On Cox proportional hazard analysis, frailty was associated with 1-year mortality only in men, after adjusting for confounding factors (hazard ratio [HR], 1.94; 95% confidence interval [CI], 1.19-3.16; P = 0.008 for men; HR, 1.63; 95% CI, 0.84-3.13; P = 0.147 for women); sarcopenia was an independent prognostic factor in both sexes (HR, 1.93; 95% CI, 1.13-3.31; P = 0.017 for men; HR, 3.18; 95% CI, 1.59-5.64; P = 0.001 for women). There were no interactions between sex and prognostic impact of frailty/sarcopenia (P = 0.806 for frailty; P = 0.254 for sarcopenia). Conclusions: Frailty and sarcopenia negatively affect older patients with heart failure from both sexes. Clinical trials: This study was registered at the University Hospital Information Network (UMINCTR, unique identifier: UMIN000023929) before the first patient was enrolled. 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

引用

页码：365 / 372

页数：8

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